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(11) |
EP 2 538 223 A8 |
| (12) |
CORRECTED EUROPEAN PATENT APPLICATION |
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Note: Bibliography reflects the latest situation |
| (15) |
Correction information: |
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Corrected version no 1 (W1 A2) |
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Corrigendum issued on: |
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27.02.2013 Bulletin 2013/09 |
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Date of publication: |
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26.12.2012 Bulletin 2012/52 |
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Date of filing: 04.11.2008 |
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| (51) |
International Patent Classification (IPC):
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| (84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL
PT RO SE SI SK TR |
| (30) |
Priority: |
05.11.2007 GB 0721713
20.11.2007 GB 0722748
15.02.2008 GB 0802814
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| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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08847014.1 / 2208073 |
| (71) |
Applicant: Nordic Bioscience A/S |
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2730 Herlev (DK) |
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| (72) |
Inventors: |
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- Karsdal, Morten
2100 Copenhagen (DK)
- Qvist, Per
DK-2930 Klampenborg (DK)
- Barascuk, Natasha
DK-2100 Kobenhavn (DK)
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| (74) |
Representative: Smart, Peter John |
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Beck Greener
Fulwood House
12 Fulwood Place
London
WC1V 6HR
London
WC1V 6HR (GB) |
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Remarks: |
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This application was filed on 19-09-2012 as a divisional application to the application
mentioned under INID code 62. |
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| (54) |
Biochemical markers for CVD risk assessment |
(57) A method of bioassay for the quantification of peptide fragments comprising a neo-epitope
formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein
the protein is decorin and said method comprises contacting a sample such as urine
or serum with an antibody reactive with the neo-epitope and determining the level
of binding of said immunological binding partner to peptide fragments in said sample.
The assay is predictive of risk of cardiovascular disease events.