Methods and probes for detecting esophageal cancer

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EP 2 540 842 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	01.06.2016 Bulletin 2016/22

(45)	Mention of the grant of the patent:
	06.04.2016 Bulletin 2016/14

(21)	Application number: 12178901.0

(22)	Date of filing: 17.02.2006

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International Patent Classification (IPC):

C12Q 1/68^(2006.01)
C07H 21/02^(2006.01)

C12P 19/34^(2006.01)
C07H 21/04^(2006.01)

(54)	Methods and probes for detecting esophageal cancer Verfahren und Sonden zur Erkennung von Speiseröhrenkrebs Procédés et sondes pour détecter un cancer de l'oesophage

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

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Priority:

18.02.2005 US 654742 P

(43)	Date of publication of application:
	02.01.2013 Bulletin 2013/01

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	06735413.4 / 1853729

(73)	Proprietors:
	Abbott Molecular Inc. Des Plaines, IL 60018 (US) Mayo Foundation for Medical Education and Research Rochester, MN 55905 (US)

(72)	Inventors:
	Halling, Kevin Rochester, Minnesota 55902 (US) Morrison, Larry, E Glen Ellen, Illinois 60137 (US) Brankley, Shannon Rochester, MN 55902 (US)

(74)	Representative: Kirkham, Nicholas Andrew et al
	Graham Watt & Co. LLP St. Botolph's House 7-9 St. Botolph's Road Sevenoaks, Kent TN13 3AJ Sevenoaks, Kent TN13 3AJ (GB)

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References cited: :

WO-A1-02/066685

FAHMY MONA ET AL: "Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimens.", MODERN PATHOLOGY : AN OFFICIAL JOURNAL OF THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY, INC MAY 2004, vol. 17, no. 5, May 2004 (2004-05), pages 588-596, XP002574692, ISSN: 0893-3952
KRISHNADATH SHEILA ET AL: "Detection of cytogenetic abnormalities by multi-color FISH in brush cytology specimens of Barrett's esophagus", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 122, no. 4 Suppl. 1, 1 April 2002 (2002-04-01), page A289, XP009131314, ISSN: 0016-5085
EL GABRY E A ET AL: "Chromosome and gene copy alterations in Barrett's Esophagus (BE)-Associated superficial esophageal adenocarcinoma: Fluorescence In Situ Hybridization (FISH) study", MODERN PATHOLOGY, vol. 18, no. Suppl. 1, January 2005 (2005-01), page 102A, XP009131391, & 94TH ANNUAL MEETING OF THE UNITED-STATES-AND-CANADIAN-ACADEMY-OF-PATH OLOGY; SAN ANTONIO, TX, USA; FEBRUARY 26 -MARCH 04, 2005 ISSN: 0893-3952
PATRAPIM SUNPAWERAVONG ET AL: "Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER, BERLIN, DE, vol. 131, no. 2, 1 February 2005 (2005-02-01), pages 111-119, XP019345377, ISSN: 1432-1335, DOI: 10.1007/S00432-004-0610-7
WALCH AXEL K ET AL: "Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequence", AMERICAN JOURNAL OF PATHOLOGY, vol. 156, no. 2, February 2000 (2000-02), pages 555-566, XP002687155, ISSN: 0002-9440
WERNER M ET AL: "[Morphology and biology of invasion with Barret's carcinoma as an example].", VERHANDLUNGEN DER DEUTSCHEN GESELLSCHAFT FÜR PATHOLOGIE 2000, vol. 84, 2000, pages 62-68, XP009164699, ISSN: 0070-4113
BRANKLEY SHANNON M ET AL: "Genetic alterations detected by FISH in endoscopic brushing specimens taken from Barrett's esophagus patients with biopsy-proven intestinal metaplasia, dysplasia or adenocarcinoma.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 46, 1 April 2005 (2005-04-01), page 446, XP002574694, & 96TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-CANCER-RESEARCH; ANAHEIM, CA, USA; APRIL 16 -20, 2005 ISSN: 0197-016X
DE PENDER A M G ET AL: "Evaluation of oncogene amplification in intact and truncated cell nuclei of gastro-esophageal cancer cell lines by DNA in situ hybridisation", ACTA HISTOCHEMICA, ELSEVIER, vol. 103, no. 2, 1 January 2001 (2001-01-01), pages 127-138, XP004631901, ISSN: 0065-1281
Kausilia Krishnawatie Krishnadath: "From Barrett's esophagus to adenocarcinoma and metastasis", , 26 June 1997 (1997-06-26), pages 1-152, XP055053906, ISBN: 978-9-05-166579-6 Retrieved from the Internet: URL:http://repub.eur.nl/res/pub/18181/9706 26_KRISHNADATH, Kausilia Krishnawatie.pdf [retrieved on 2013-02-19]
SVETLANA D. PACK ET AL: "Molecular cytogenetic fingerprinting of esophageal squamous cell carcinoma by comparative genomic hybridization reveals a consistent pattern of chromosomal alterations", GENES, CHROMOSOMES AND CANCER, vol. 25, no. 2, 1 June 1999 (1999-06-01), pages 160-168, XP055053918, ISSN: 1045-2257, DOI: 10.1002/(SICI)1098-2264(199906)25:2<160::A ID-GCC12>3.0.CO;2-U
BRANKLEY SHANNON M ET AL: "The development of a fluorescence in situ hybridization assay for the detection of dysplasia and adenocarcinoma in Barrett's esophagus", JOURNAL OF MOLECULAR DIAGNOSTICS, vol. 8, no. 2, May 2006 (2006-05), pages 260-267, XP002692403, ISSN: 1525-1578

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