(19)
(11) EP 2 542 560 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
30.12.2015 Bulletin 2015/53

(45) Mention of the grant of the patent:
11.11.2015 Bulletin 2015/46

(21) Application number: 11751437.2

(22) Date of filing: 04.03.2011
(51) International Patent Classification (IPC): 
C07F 9/14(2006.01)
C07F 9/26(2006.01)
A61P 9/12(2006.01)
 C07F 9/20(2006.01)
A61K 31/683(2006.01)
(86) International application number:
PCT/US2011/027232
(87) International publication number:
WO 2011/109731 (09.09.2011 Gazette 2011/36)

(54)

ARYLFLUOROPHOSPHATE INHIBITORS OF INTESTINAL APICAL MEMBRANE SODIUM/PHOSPHATE CO-TRANSPORT

ARYLFLUORPHOSPHATHEMMER EINES NATRIUM-/PHOSPHAT-TRANSPORTS DURCH APIKALMEMBRANEN IM DARM

INHIBITEURS DU COTRANSPORT SODIUM/PHOSPHATE DANS LA MEMBRANE APICALE INTESTINALE À BASE DE FLUOROPHOSPHATES D'ARYLE

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 05.03.2010 US 310902 P

(43) Date of publication of application:
09.01.2013 Bulletin 2013/02

(73) Proprietor: Duophos
Friendswood, TX 77546 (US)

(72) Inventors:
  • PEERCE, Brian
    Friendswood, TX 77546 (US)
  • SLOMOWITZ, Larry
    Vancouver, BC V6H 3H9 (CA)

(74) Representative: Williams, Andrea et al
Marks & Clerk LLP 62-68 Hills Road
Cambridge CB2 1LA
Cambridge CB2 1LA (GB)


(56) References cited: : 
WO-A2-00/43402
   
  • PEERCE, B. E. ET AL.: 'A Phosphorylated Phloretin Derivative. Synthesis and Effect on Intestinal Na+-dependant Phosphate Absorption.' AM. J. PHYSIOL. GASTROINTEST. LIVER PHYSIOL. vol. 283, 2002, pages G848 - G855, XP055096590
  • DABKOWSKI, W. ET AL.: 'Synthesis of Phosphorofluoridates and Phosphofluoridot hioates via the Phosphoramidite Approach.' ORG. BIOMOL. CHEM. vol. 3, 2005, pages 866 - 874, XP055096591
  • PEERCE, B. E.: 'Effect of Substrates and pH on the Intestinal Na+/Phosphate Cotransporter: Evidence for an Intervesicular Divalent Phosphate Allosteric Regulatory Site.' BIOCHIMICA ET BIOPHYSICA ACTA vol. 1239, no. 1, 1995, pages 1 - 10, XP055096617
  • ROMANENKO, V. D. ET AL.: 'Fluorinated Organophosphates for Biomedical Targets.' TETRAHEDRON vol. 64, 2008, pages 6153 - 6190, XP022695588
  • ALKHERRAZ, A. ET AL.: 'Phosphate Ester Analogues as Probes for Understanding Enzyme Catalysed Phosphoryl Transfer.' FARADAY DISCUSS. vol. 145, 29 October 2009, pages 281 - 299, XP055096606
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).