| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
|
Designated Extension States: |
|
BA ME |
| (30) |
Priority: |
26.07.2010 US 367855 P
08.01.2010 US 293612 P
|
| (43) |
Date of publication of application: |
|
09.01.2013 Bulletin 2013/02 |
| (60) |
Divisional application: |
|
17197865.3 |
| (73) |
Proprietors: |
|
- Progastrine et Cancers S.à r.l.
1450 Luxembourg (LU)
- Institut National de la Santé et de la
Recherche Médicale (INSERM)
75654 Paris Cedex 13 (FR)
- Centre National de la Recherche Scientifique
(CNRS)
75794 Paris Cedex 16 (FR)
|
|
| (72) |
Inventors: |
|
- PANNEQUIN, Julie
34200 Sète (FR)
- HOUHOU, Leïla
34090 Montpellier (FR)
- FRAMERY, Bérénice
34070 Montpellier (FR)
- ERKILIC, Nejla
34990 Juvignac (FR)
- JOUBERT, Dominique
34200 Sète (FR)
- HOLLANDE, Frédéric
34790 Grabels (FR)
|
| (74) |
Representative: Regimbeau |
|
La Coupole Sud
379, rue Léon Blum
34000 Montpellier
34000 Montpellier (FR) |
| (56) |
References cited: :
WO-A1-2006/032980
WO-A1-2009/099649
WO-A2-2007/135542
US-A1- 2009 275 546
|
WO-A1-2008/076454
WO-A2-2004/090547
US-A1- 2001 039 017
|
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| |
|
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- SIDDHESHWAR R K ET AL: "Plasma levels of progastrin but not amidated gastrin or glycine
extended gastrin are elevated in patients with colorectal carcinoma", GUT, BRITISH
MEDICAL ASSOCIATION, LONDON, UK, vol. 48, no. 1, 1 January 2001 (2001-01-01), pages
47-52, XP002398546, ISSN: 0017-5749, DOI: DOI:10.1136/GUT.48.1.47
- SINGH P ET AL: "GASTRIN GENE EXPRESSION IS REQUIRED FOR THE PROLIFERATION AND TUMORIGENICITY
OF HUMAN COLON CANCER CELLS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER REREARCH,
US, vol. 56, no. 18, 15 September 1996 (1996-09-15), pages 4111-4115, XP008057032,
ISSN: 0008-5472
- PANNEQUIN ET AL: "beta-Catenin/Tcf-4 Inhibition After Progastrin Targeting Reduces
Growth and Drives Differentiation of Intestinal Tumors", GASTROENTEROLOGY, ELSEVIER,
PHILADELPHIA, PA, vol. 133, no. 5, 24 October 2007 (2007-10-24), pages 1554-1568,
XP022407062, ISSN: 0016-5085, DOI: DOI:10.1053/J.GASTRO.2007.08.023
- HOLLANDE FRÉDÉRIC ET AL: "Adherens junctions and tight junctions are regulated via
different pathways by progastrin in epithelial cells", JOURNAL OF CELL SCIENCE, CAMBRIDGE
UNIVERSITY PRESS, LONDON, GB, vol. 116, no. Pt 7, 1 April 2003 (2003-04-01), pages
1187-1197, XP002511534, ISSN: 0021-9533, DOI: DOI:10.1242/JCS.00321
- SINGH POMILA ET AL: "Development of progastrin (PG) specific monoclonal antibodies
(MAbs) and PG specific vaccine for attenuating growth factor effects of autocrine
and endocrine PG-like pepticles on colon cancer cells and colon carcinogenesis, respectively.",
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 48,
April 2007 (2007-04), page 845, XP9146815, & 98TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-CANCER-RESEARCH;
LOS ANGELES, CA, USA; APRIL 14 -18, 2007 ISSN: 0197-016X
- CICCOTOSTO G D ET AL: "Expression, processing, and secretion of gastrin in patients
with colorectal carcinoma.", GASTROENTEROLOGY OCT 1995 LNKD- PUBMED:7557079, vol.
109, no. 4, October 1995 (1995-10), pages 1142-1153, XP002631233, ISSN: 0016-5085
- SINGH POMILA ET AL: "Mice overexpressing progastrin are predisposed for developing
aberrant colonic crypt foci in response to AOM", 20000301, vol. 278, no. 3 part 1,
1 March 2000 (2000-03-01), pages G390-G399, XP002188103,
- SINGH P ET AL: "PROGASTRIN EXPRESSION PREDISPOSES MICE TO COLON CARCINOMAS AND ADENOMAS
IN RESPONSE TO A CHEMICAL CARCINOGEN", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA,
vol. 119, no. 1, 1 January 2000 (2000-01-01), pages 162-171, XP001053110, ISSN: 0016-5085,
DOI: DOI:10.1053/GAST.2000.8527
- HECHT J RANDOLPH: "Current and emerging therapies for metastatic colorectal cancer:
applying research findings to clinical practice", AMERICAN JOURNAL OF HEALTH-SYSTEM
PHARMACY, AMERICAN SOCIETY OF HEALTH-SYSTEM PHARMACISTS, UNITED STATES, vol. 65, no.
11, suppl. 4, 1 June 2008 (2008-06-01), pages S15-S24, XP009126612, ISSN: 1079-2082,
DOI: DOI:10.2146/AJHP080102
- AKIHIRO TAMIYA ET AL: "Safety of bevacizumab treatment in combination with standard
chemotherapy for metastatic colorectal cancer: a retrospective review of 65 Japanese
patients", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, SPRINGER-VERLAG, TO, vol. 14,
no. 6, 5 December 2009 (2009-12-05), pages 513-517, XP019763960, ISSN: 1437-7772,
DOI: DOI:10.1007/S10147-009-0911-6
- JEAN GARY W AND SHAH SACHIN R: "Epidermal growth factor receptor monoclonal antibodies
for the treatment of metastatic colorectal cancer", PHARMACOTHERAPY, BOSTON, US, vol.
28, no. 6, 1 June 2008 (2008-06-01), pages 742-754, XP008123162, ISSN: 0277-0008
- PETKOVA STEFKA B ET AL: "Enhanced half-life of genetically engineered human IgG1 antibodies
in a humanized FcRn mouse model: potential application in humorally mediated autoimmune
disease", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 18, no. 12,
1 December 2006 (2006-12-01), pages 1759-1769, XP002539987, ISSN: 0953-8178, DOI:
DOI:10.1093/INTIMM/DXL110
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