(19)

(11)

EP 2 545 039 A1

(12)

(43) Date of publication: 16.01.2013 Bulletin 2013/03 (21) Application number: 10708939.3 (22) Date of filing: 10.03.2010

(51) International Patent Classification (IPC):  C07D 239/30(2006.01) C07D 403/06(2006.01) (86) International application number: PCT/EP2010/001607 (87) International publication number: WO 2011/110198 (15.09.2011 Gazette 2011/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (71) Applicant: Synthon BV 6545 CM Nijmegen (NL)	(72) Inventors: OVEREEM, Arjanne NL-6642 ED Beuningen (NL) ZHU, Jie NL-6538 Nijmegen (NL) (74) Representative: van den Broek, Ludovicus A.G.M.  Synthon B.V. IP Research P.O. Box 7071 6503 GN Nijmegen 6503 GN Nijmegen (NL)