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EP 2 550 258 A2

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(88) Date of publication A3: 22.12.2011 (43) Date of publication: 30.01.2013 Bulletin 2013/05 (21) Application number: 11709579.4 (22) Date of filing: 10.03.2011

(51) International Patent Classification (IPC):  C07D 295/112(2006.01) C07D 417/04(2006.01) C07C 311/51(2006.01) A61K 31/495(2006.01) A61P 35/00(2006.01) C07D 295/195(2006.01) C07D 211/58(2006.01) A61K 31/451(2006.01) A61K 31/18(2006.01) (86) International application number: PCT/US2011/027895 (87) International publication number: WO 2011/119345 (29.09.2011 Gazette 2011/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 25.03.2010 US 317575 P (71) Applicant: Abbvie Inc. North Chicago, IL 60064 (US)

(72) Inventors: DING, Hong Lincolnshire, Illinois 60069 (US) ELMORE, Steven Northbrook, Illinois 60062 (US) HEXAMER, Laura Grayslake, Illinois 60030 (US) KUNZER, Aaron, R. Arlington, Illinois 60004 (US) PARK, Cheol-Min Singapore 637371 (SG) SOUERS, Andrew, J. Evanston, Illinois 60202 (US) SULLIVAN, Gerard Lake Villa, Illinois 60046 (US) WENDT, Michael Vernon Hills, Illinois 60061 (US) (74) Representative: Modiano, Micaela Nadia et al Modiano & Partners (DE) Thierschstrasse 11 80538 München 80538 München (DE)