2',2-DITHIAZOL NON-NUCLEOSIDE COMPOUNDS, PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND USES AS HEPATITIS VIRUS INHIBITORS THEREOF

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(11)

EP 2 551 266 A8

(12)	CORRECTED EUROPEAN PATENT APPLICATION
	published in accordance with Art. 153(4) EPC

(15)	Correction information:
	Corrected version no 1 (W1 A1)

(48)	Corrigendum issued on:
	29.05.2013 Bulletin 2013/22

(43)	Date of publication:
	30.01.2013 Bulletin 2013/05

(21)	Application number: 11758773.3

(22)	Date of filing: 16.03.2011

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International Patent Classification (IPC):

C07D 277/56^(2006.01)
A61P 31/20^(2006.01)

A61K 31/427^(2006.01)
A61P 31/14^(2006.01)

(86)	International application number:
	PCT/CN2011/071851

(87)	International publication number:
	WO 2011/116663 (29.09.2011 Gazette 2011/39)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

24.03.2010 CN 201010131636

(71)	Applicant: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
	Shanghai 201203 (CN)

(72)	Inventors:
	NAN, Fajun Shanghai 201203 (CN) ZUO, Jianping Shanghai 201203 (CN) ZHANG, Yangming Shanghai 201203 (CN) TANG, Wei Shanghai 201203 (CN)

(74)	Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser
	Leopoldstrasse 4 80802 München 80802 München (DE)

(54)	2',2-DITHIAZOL NON-NUCLEOSIDE COMPOUNDS, PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND USES AS HEPATITIS VIRUS INHIBITORS THEREOF

(57) The present disclusure belongs to the field of pharmaceutical chemistry, and relates to a class of 2',2-bisthiazole non-nucleoside compounds of following formula I, the preparation method and the pharmaceutical composition thereof. The compounds have both the anti-HBV and anti-HCV activities and are useful in treating hepatitides B and C. Pharmacokinetic tests showed the compounds have good bioavailability.