(19)
(11) EP 2 553 099 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 2 (W2 B1)

(48) Corrigendum issued on:
12.08.2015 Bulletin 2015/33

(45) Mention of the grant of the patent:
24.06.2015 Bulletin 2015/26

(21) Application number: 11761888.4

(22) Date of filing: 30.03.2011
(51) International Patent Classification (IPC): 
C12N 15/12(2006.01)
C12Q 1/68(2006.01)
C07H 21/04(2006.01)
C07K 14/435(2006.01)
(86) International application number:
PCT/CA2011/050169
(87) International publication number:
WO 2011/120165 (06.10.2011 Gazette 2011/40)

(54)

MACROCYCLIC LACTONE RESISTANCE MARKER FOR DIROFILARIA IMMITIS

MARKER FÜR DIE RESISTENZ GEGEN MAKROZYKLISCHE LACTONE FÜR HERZWÜRMER

MARQUEUR DE RÉSISTANCE À LA LACTONE MACROCYCLIQUE POUR DIROFILARIA IMMITIS


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 01.04.2010 US 319982 P

(43) Date of publication of application:
06.02.2013 Bulletin 2013/06

(73) Proprietors:
  • Novartis Tiergesundheit AG
    4058 Basel (CH)
  • The Royal Institution For The Advancement Of Learning/McGill University
    Montreal, Québec H3A 0G4 (CA)

(72) Inventors:
  • PRICHARD, Roger
    Ste-Anne-de-Bellevue, Québec H9X 3W6 (CA)
  • BOURGUINAT, Catherine
    Montreal, Québec H2X 2H7 (CA)
  • GEARY, Timothy
    Ste-Anne-de-Bellevue, Québec H9X 3L4 (CA)
  • SCHENKER, Rudolf
    CH-4002 Basel (CH)

(74) Representative: Spinner, David Richard 
Greaves Brewster LLP Copa House Station Road
Cheddar, Somerset BS27 3AH
Cheddar, Somerset BS27 3AH (GB)


(56) References cited: : 
EP-B1- 0 979 278
   
  • DATABASE EMBL [Online] 19 April 2007 (2007-04-19), "Wang-VSVGgfp-Jurkat-454-Avr-006514_1396_1 300 Wang-VSVGgfp-Jurkat-454-Avr Homo sapiens genomic, genomic survey sequence.", XP002708500, retrieved from EBI accession no. EM_GSS:EI523665 Database accession no. EI523665
  • PRICHARD ROGER K: "Ivermectin resistance and overview of the Consortium for Anthelmintic Resistance SNPs.", EXPERT OPINION ON DRUG DISCOVERY OCT 2007, vol. 2, no. s1, October 2007 (2007-10), pages S41-S52, XP009171670, ISSN: 1746-0441
  • CATHERINE BOURGUINAT ET AL: "Macrocyclic lactone resistance in Dirofilaria immitis", VETERINARY PARASITOLOGY, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 181, no. 2, 16 April 2011 (2011-04-16), pages 388-392, XP028286326, ISSN: 0304-4017, DOI: 10.1016/J.VETPAR.2011.04.012 [retrieved on 2011-04-16]
  • JEFFREY N. CLARK: "Comment on the paper "Macrocyclic lactone resistance in Dirofilaria immitis" by Bourguinat et al.", VETERINARY PARASITOLOGY, vol. 182, no. 2-4, 15 June 2011 (2011-06-15), pages 378-379, XP055073832, ISSN: 0304-4017, DOI: 10.1016/j.vetpar.2011.06.009
  • TIMOTHY G GEARY ET AL: "Evidence for Macrocyclic Lactone Anthelmintic Resistance in", TOPICS IN COMPANION ANIMAL MEDICINE, vol. 26, no. 4, November 2011 (2011-11), pages 186-192, XP028337100, ISSN: 1938-9736, DOI: 10.1053/J.TCAM.2011.09.004 [retrieved on 2011-10-08]
  • BOURGUINAT, C. ET AL.: 'P-glycoprotein-like protein, a possible genetic marker for invermectin resistance selection in Onchocerca volvulus.' MOL. BIOCHEM. PARASITOL. vol. 158, 2008, pages 101 - 111, XP022485730
  • MEALEY, K. L.: 'Canine ABCB1 and macrocyclic lactones: Heartworm prevention and pharmacogenetics.' VET. PARASITOL. vol. 158, 2008, pages 215 - 222, XP025633063
  • BOURGUINAT, C. ET AL.: 'Correlation between loss of efficacy of macrocyclic lactone heartworm anthemlintics and P-glycoprotein genotype.' VET. PARASITOL. vol. 176, 22 March 2011, pages 374 - 381, XP028156255
  • BOURGUINAT, C. ET AL.: 'Genetic polymorphism in Dirofilaria immitus.' VET. PARASITOL. vol. 176, 22 March 2011, pages 368 - 373, XP028156254
  • DATABASE GENBANK 11 March 2011 BOURGUINAT, C. ET AL., XP008161229 Database accession no. HM596853
   
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