(19)

(11)

EP 2 561 345 A2

(12)

(88) Date of publication A3: 02.02.2012 (43) Date of publication: 27.02.2013 Bulletin 2013/09 (21) Application number: 11766589.3 (22) Date of filing: 05.04.2011

(51) International Patent Classification (IPC):  G01N 30/60(2006.01) (86) International application number: PCT/US2011/031234 (87) International publication number: WO 2011/127044 (13.10.2011 Gazette 2011/41)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 05.04.2010 US 321098 P (71) Applicant: Purdue Research Foundation West Lafayette, IN 47906 (US)	(72) Inventors: WIRTH, Mary, Jean West Lafayette IN 47906 (US) RANASINGHE KODITHUWAKKUGE, Sampath West Lafayette, IN 47906 (US) YERNENI, Charu West Lafayette IN 47906 (US) BIRDSALL, Robert West Lafayette IN 47906 (US) (74) Representative: Kremer, Simon Mark et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)