COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES

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(11)

EP 2 562 156 A8

(12)	CORRECTED EUROPEAN PATENT APPLICATION
	published in accordance with Art. 153(4) EPC

(15)	Correction information:
	Corrected version no 1 (W1 A2)

(48)	Corrigendum issued on:
	30.04.2014 Bulletin 2014/18

(43)	Date of publication:
	27.02.2013 Bulletin 2013/09

(21)	Application number: 11744910.8

(22)	Date of filing: 18.02.2011

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International Patent Classification (IPC):

C07C 271/24^(2006.01)
A61K 31/165^(2006.01)

C07C 233/32^(2006.01)
A61P 37/02^(2006.01)

(86)	International application number:
	PCT/KR2011/001087

(87)	International publication number:
	WO 2011/102668 (25.08.2011 Gazette 2011/34)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

18.02.2010 KR 20100014811

(71)	Applicant: The Asan Foundation
	Seoul, 138-736 (KR)

(72)	Inventors:
	HAN, Duck Jong Seoul 138-797 (KR) YOO, Sung-eun Chungcheongnam-do, 314-911 (KP) SUH, Jeehee Daejeon, 305-755 (KR)

(74)	Representative: Lusuardi, Werther
	Dr. Lusuardi AG Kreuzbühlstrasse 8 8008 Zürich 8008 Zürich (CH)

(54)	COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES

(57) The present invention relates to colchicine derivatives expressed in chemical formula 1, or to pharmaceutically acceptable salts thereof, to a method for preparing said derivatives, and to a pharmaceutical composition comprising said derivatives. The colchicine derivatives according to the present invention exhibit superior immunomodulatory effects as compared with conventional immunomodulators or colchicines, and therefore can be valuably used as an immunomodulator for modulating an acute or chronic immune response in organ transplantation.