(19)
(11) EP 2 564 864 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
13.05.2015 Bulletin 2015/20

(45) Mention of the grant of the patent:
24.12.2014 Bulletin 2014/52

(21) Application number: 12193871.6

(22) Date of filing: 13.11.2006
(51) International Patent Classification (IPC): 
A61K 38/00(2006.01)
C12M 1/34(2006.01)
C07H 21/04(2006.01)
G01N 33/50(2006.01)
 C12Q 1/68(2006.01)
C07H 21/02(2006.01)
A61K 38/18(2006.01)

(54)

FGF2-related methods for diagnosing and treating depression

Verfahren im Zusammenhang mit FGF2 zur Diagnose und Behandlung von Depressionen

Méthodes associées au FGF2 pour diagnostiquer et traiter une dépression

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 12.11.2005 US 736526 P
13.10.2006 US 829516 P

(43) Date of publication of application:
06.03.2013 Bulletin 2013/10

(62) Application number of the earlier application in accordance with Art. 76 EPC:
06844345.6 / 1951908

(73) Proprietor: The Board of Trustees of the Leland Stanford Junior University
Palo Alto, CA 94306-1106 (US)

(72) Inventors:
  • Akil, Huda
    Ann Arbor, MI 48105 (US)
  • Watson, Stanley J.
    Ann Arbor, MI 48105 (US)
  • Evans, Simon J.
    Milan, MI 48160 (US)
  • Turner, Cortney
    Belleville, MI 48111 (US)
  • Bernard, René
    10115 Berlin (DE)
  • Kerman, Ilan
    Ann Arbor, MI 48105 (US)
  • Thompson, Robert C.
    Ann Arbor, MI 48108 (US)
  • Burmeister, Margit
    Ann Arbor, MI 48105 (US)
  • Scott, Laura J.
    Ann Arbor, MI 48104 (US)
  • Meng, Fan
    Ann Arbor, MI 48103 (US)
  • Boehnke, Michael
    Ann Arbor, MI 48103 (US)
  • Bunney, William E. Jr.
    Laguna Hills, CA 92651 (US)
  • Vawter, Marquis P.
    Laguna Niguel, CA 92677 (US)
  • Jones, Edward G.
    Winters, CA 95694 (US)
  • Choudary, Prabhakara V.
    Davis, CA 95616 (US)
  • Myers, Richard M.
    Huntsville, AL 35806 (US)
  • Schatzberg, Alan F.
    Los Altos, CA 94024 (US)
  • Li, Jun
    Palo Alto, CA 94306 (US)
  • Absher, Devin
    Huntsville, AL 35801 (US)
  • Tomita, Hiroaki
    Irvine, CA 92612 (US)
  • Lyons, David Michael
    Menlo Park, C 94025 (US)

(74) Representative: Campbell, Patrick John Henry 
J A Kemp 14 South Square Gray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)


(56) References cited: : 
EP-A- 1 586 657
WO-A2-2004/056865
 WO-A-2005/046434
WO-A2-2005/014623
   
  • EVANS S J ET AL: "Dysregulation of the fibroblast growth factor system in major depression.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 26 OCT 2004, vol. 101, no. 43, 26 October 2004 (2004-10-26), pages 15506-15511, XP002552309, ISSN: 0027-8424
  • SACHS GARY S ET AL: "Effectiveness of adjunctive antidepressant treatment for bipolar depression.", THE NEW ENGLAND JOURNAL OF MEDICINE 26 APR 2007, vol. 356, no. 17, 26 April 2007 (2007-04-26), pages 1711-1722, ISSN: 1533-4406
  • BARBEE JAMES G ET AL: "A double-blind placebo-controlled trial of lamotrigine as an antidepressant augmentation agent in treatment-refractory unipolar depression.", THE JOURNAL OF CLINICAL PSYCHIATRY OCT 2011, vol. 72, no. 10, October 2011 (2011-10), pages 1405-1412, ISSN: 1555-2101
  • FDA: 'Valproate Information', [Online] FDA Retrieved from the Internet: <URL:http://www.fda.gov/drugs/drugsafety/po stmarketdrugsafetyinformationforpatientsand providers/ucm192645.htm> [retrieved on 2014-07-10]
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).