(19)
(11) EP 2 567 965 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 A1)

(48) Corrigendum issued on:
19.06.2013 Bulletin 2013/25

(88) Date of publication A3:
13.03.2013 Bulletin 2013/11

(43) Date of publication:
13.03.2013 Bulletin 2013/11

(21) Application number: 11306138.6

(22) Date of filing: 12.09.2011
(51) International Patent Classification (IPC): 
C07J 5/00(2006.01)
A61P 31/18(2006.01)
C07J 63/00(2006.01)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(71) Applicants:
  • Centre National de la Recherche Scientifique (CNRS)
    75016 Paris (FR)
  • UNIVERSITE PARIS DESCARTES
    75006 Paris (FR)

(72) Inventors:
  • Bouaziz, Serge
    93100 Montreuil (FR)
  • Coric, Pascale
    75012 Paris (FR)
  • Boulanger, Pierre
    69006 Lyon (FR)
  • Hong, Saw-See
    69006 Lyon (FR)
  • Turcaud, Serge
    78500 Sartrouville (FR)
  • Souquet, Florence
    77600 Jossigny (FR)
  • Chazal, Nathalie
    30320 Marguerittes (FR)
  • Briant, Laurence
    30660 Gallargues-le-Monteux (FR)

(74) Representative: Regimbeau 
20, rue de Chazelles
75847 Paris Cedex 17
75847 Paris Cedex 17 (FR)

   


(54) Derivatives of 3-O-(3',3'-dimethylsuccinyl)-betulinic acid


(57) The present invention relates to compounds of the following formula (I):

or a pharmaceutically acceptable salt thereof, a stereoisomer or a mixture of stereoisomers in any proportion, in particular a mixture of enantiomers, and particularly a racemate mixture,
in which R represents a (C1-C10)alkyl group substituted with one or more, preferably one or two, groups chosen from COOH and NHR1,
with R1 representing a hydrogen atom or a -Alk, -C(O)-Alk or -C(O)O-Alk group, Alk representing a (C1-C6)alkyl group,
as well as a method for preparing them, and their use as a medicine, notably for treating an infection with a retrovirus such as HIV.