(19)

(11)

EP 2 571 360 A1

(12)

(43) Date of publication: 27.03.2013 Bulletin 2013/13 (21) Application number: 11784249.2 (22) Date of filing: 19.05.2011

(51) International Patent Classification (IPC):  A01N 43/82(2006.01) A61K 31/41(2006.01) (86) International application number: PCT/US2011/037169 (87) International publication number: WO 2011/146726 (24.11.2011 Gazette 2011/47)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 19.05.2010 US 346347 P (71) Applicant: The University of North Carolina At Chapel Hill Chapel Hill, NC 27599-4105 (US)	(72) Inventors: PEDERSEN, Cort A. Durham North Carolina 27707 (US) BOCCIA, Maria L. Charlotte North Carolina 28278 (US) KAMPOV-POLEVOI, Alexei Chapel Hill North Carolina 27514 (US) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)