(19)
(11) EP 2 575 898 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.04.2021 Bulletin 2021/16

(45) Mention of the grant of the patent:
30.09.2020 Bulletin 2020/40

(21) Application number: 11722429.5

(22) Date of filing: 30.05.2011
(51) International Patent Classification (IPC): 
A61K 51/04(2006.01)
C07B 59/00(2006.01)
A61K 101/02(2006.01)
C07C 213/08(2006.01)
(86) International application number:
PCT/EP2011/058819
(87) International publication number:
WO 2011/151282 (08.12.2011 Gazette 2011/49)

(54)

METHOD FOR PRODUCTION OF F-18 LABELED AMYLOID BETA LIGAND

VERFAHREN ZUR HERSTELLUNG VON F-18-MARKIERTEN AMYLOID-BETA-LIGANDEN

PROCÉDÉ DE PRODUCTION DE LIGAND DE L'AMYLOÏDE BÊTA MARQUÉ AU 18F


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 04.06.2010 EP 10164948

(43) Date of publication of application:
10.04.2013 Bulletin 2013/15

(73) Proprietor: Life Molecular Imaging SA
1753 Matran (CH)

(72) Inventors:
  • BERNDT, Mathias
    12163 Berlin (DE)
  • FRIEBE, Matthias
    13509 Berlin (DE)
  • HULTSCH, Christina
    12101 Berlin (DE)
  • SAMSON, Fabrice
    Seoul 140-858 (KR)
  • OH, Seung, Jun
    Seoul 150-045 (KR)
  • SMUDA, Christoph
    CH-8952 Schlieren (CH)

(74) Representative: Kilger, Ute 
Boehmert & Boehmert Anwaltspartnerschaft mbB Pettenkoferstrasse 22
80336 München
80336 München (DE)


(56) References cited: : 
WO-A1-2010/078370
WO-A2-2010/000409
US-A1- 2010 113 763
WO-A1-2011/003591
US-A1- 2006 269 473
   
  • ZHANG ET AL: "F-18 Polyethyleneglycol stilbenes as PET imaging agents targeting Abeta aggregates in the brain", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US, vol. 32, no. 8, 1 November 2005 (2005-11-01), pages 799-809, XP005129336, ISSN: 0969-8051, DOI: 10.1016/J.NUCMEDBIO.2005.06.001 cited in the application
  • WANG H ET AL: "Facile and rapid one-step radiosynthesis of [<18>F]BAY94-9172 with a new precursor", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US, vol. 38, no. 1, 1 January 2011 (2011-01-01), pages 121-127, XP027589497, ISSN: 0969-8051 [retrieved on 2010-08-16] cited in the application
  • PATT M ET AL: "Metabolite analysis of [18F]Florbetaben (BAY 94-9172) in human subjects: a substudy within a proof of mechanism clinical trial", JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 284, no. 3, 16 March 2010 (2010-03-16), pages 557-562, XP019792449, ISSN: 1588-2780
  • LIN K J ET AL: "Whole-body biodistribution and brain PET imaging with [<18>F]AV-45, a novel amyloid imaging agent - a pilot study", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US, vol. 37, no. 4, 1 May 2010 (2010-05-01), pages 497-508, XP027039103, ISSN: 0969-8051 [retrieved on 2010-04-07]
  • LIU Y ET AL: "Optimization of automated radiosynthesis of [<18>F]AV-45: a new PET imaging agent for Alzheimer's disease", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US, vol. 37, no. 8, 1 November 2010 (2010-11-01), pages 917-925, XP027472064, ISSN: 0969-8051, DOI: 10.1016/J.NUCMEDBIO.2010.05.001 [retrieved on 2010-06-29] cited in the application
  • YAO C H ET AL: "GMP-compliant automated synthesis of [<18>F]AV-45 (Florbetapir F 18) for imaging beta-amyloid plaques in human brain", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD, GB, vol. 68, no. 12, 1 December 2010 (2010-12-01), pages 2293-2297, XP027265706, ISSN: 0969-8043 [retrieved on 2010-07-07] cited in the application
  • PIYUSH KUMAR ET AL: "18F-FESB: synthesis and automated radiofluorination of a novel18F-labeled pet tracer for[beta]-amyloid plaques", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 48, no. 13, 1 November 2005 (2005-11-01), pages 983-996, XP55006268, ISSN: 0362-4803, DOI: 10.1002/jlcr.1011
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).