(19)
(11) EP 2 576 585 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.12.2016 Bulletin 2016/51

(45) Mention of the grant of the patent:
12.10.2016 Bulletin 2016/41

(21) Application number: 11726563.7

(22) Date of filing: 02.06.2011
(51) International Patent Classification (IPC): 
C07J 63/00(2006.01)
A61P 31/18(2006.01)
 A61P 31/12(2006.01)
A61K 31/56(2006.01)
(86) International application number:
PCT/US2011/038879
(87) International publication number:
WO 2011/153315 (08.12.2011 Gazette 2011/49)

(54)

MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS

MODIFIZIERTE C-3-BETULINSÄUREDERIVATE ALS HIV-REIFUNGSHEMMER

DÉRIVÉS D'ACIDE BÉTULINIQUE MODIFIÉS EN C-3, UTILISÉS COMME INHIBITEURS DE MATURATION DU VIH

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 04.06.2010 US 351338 P

(43) Date of publication of application:
10.04.2013 Bulletin 2013/15

(73) Proprietor: VIIV Healthcare UK (No.5) Limited
Brentford Middlesex TW8 9GS (GB)

(72) Inventors:
  • REGUEIRO-REN, Alicia
    Wallingford Connecticut 06492 (US)
  • SWIDORSKI, Jacob
    Wallingford Connecticut 06492 (US)
  • LIU, Zheng
    Wallingford Connecticut 06492 (US)
  • MEANWELL, Nicholas A.
    Wallingford Connecticut 06492 (US)
  • SIT, Sing-Yuen
    Wallingford Connecticut 06492 (US)
  • CHEN, Jie
    Wallingford Connecticut 06492 (US)

(74) Representative: Learoyd, Stephanie Anne et al
GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road
Brentford, Middlesex TW8 9GS
Brentford, Middlesex TW8 9GS (GB)


(56) References cited: : 
WO-A1-99/45025
 WO-A2-2005/112929
   
  • ZHU Y-M ET AL: "Synthesis and Anti-HIV Activity of Oleanolic Acid Derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 11, no. 24, 1 December 2001 (2001-12-01), pages 3115-3118, XP002984538, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(01)00647-3
  • MA C ET AL: "CHEMICAL MODIFICATION OF OLEANENE TYPE TRITERPENES AND THEIR INHIBITORY ACTIVITY AGAINST HIV-1 PROTEASE DIMERIZATION", CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, vol. 48, no. 11, 1 November 2000 (2000-11-01), pages 1681-1688, XP001208133, ISSN: 0009-2363
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).