| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
23.06.2010 GB 201010557
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| (43) |
Date of publication of application: |
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01.05.2013 Bulletin 2013/18 |
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Proprietor: MiNA Therapeutics Limited |
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London, W12 0BZ (GB) |
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Inventor: |
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- SÆTROM, Pål
NO-7023 Trondheim (NO)
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| (74) |
Representative: Hoffmann Eitle |
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Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München
81925 München (DE) |
| (56) |
References cited: :
WO-A1-2010/047216
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WO-A2-2009/046397
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- KEVIN V. MORRIS ET AL: "Bidirectional Transcription Directs Both Transcriptional Gene
Activation and Suppression in Human Cells", PLOS GENETICS, vol. 4, no. 11, 1 January
2008 (2008-01-01), page E1000258, XP055008804, ISSN: 1553-7390, DOI: 10.1371/journal.pgen.1000258
- LI LONG-CHENG ET AL: "Small dsRNAs induce transcriptional activation in human cells",
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE,
WASHINGTON, DC; US, vol. 103, no. 46, 14 November 2006 (2006-11-14), pages 17337-17342,
XP002589998, ISSN: 0027-8424, DOI: 10.1073/PNAS.0607015103 [retrieved on 2006-11-03]
- SCHWARTZ J C ET AL: "Antisense transcripts are targets for activating small RNAs",
NATURE STRUCTURAL & MOLECULAR BIOLOGY,, vol. 15, no. 8, 6 July 2008 (2008-07-06),
pages 842-848, XP009109339, ISSN: 1545-9985, DOI: 10.1038/NSMB.1444
- PLACE ROBERT F ET AL: "MicroRNA-373 induces expression of genes with complementary
promoter sequences", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL
ACADEMY OF SCIENCE, WASHINGTON, DC; US, vol. 105, no. 5, 5 February 2008 (2008-02-05),
pages 1608-1613, XP002548636, ISSN: 0027-8424, DOI: 10.1073/PNAS.0707594105 [retrieved
on 2008-01-28]
- NA XU ET AL: "MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency
in Human Embryonic Stem Cells", CELL, vol. 137, no. 4, 1 May 2009 (2009-05-01), pages
647-658, XP055008854, ISSN: 0092-8674, DOI: 10.1016/j.cell.2009.02.038
- JANOWSKI B A ET AL: "Activating gene expression in mammalian cells with promoter-targeted
duplex RNAs", NATURE CHEMICAL BIOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US,
vol. 3, no. 3, 28 January 2007 (2007-01-28), pages 166-173, XP003026584, ISSN: 1552-4450,
DOI: 10.1038/NCHEMBIO860
- ELMÉN J ET AL: "Antagonism of microRNA-122 in mice by sistemically administered LNA-antimiR
leads to up-regulation of a large set of predicted target mRNAs in the liver", NUCLEIC
ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 36, no. 4, 23 December 2007
(2007-12-23), pages 1153-1162, XP002533568, ISSN: 0305-1048, DOI: 10.1093/NAR/GKM1113
- Y. TIAN ET AL: "MicroRNA-10b Promotes Migration and Invasion through KLF4 in Human
Esophageal Cancer Cell Lines", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 11,
12 March 2010 (2010-03-12), pages 7986-7994, XP055008850, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.062877
- SARA NAPOLI ET AL: "Promoter-specific transcriptional interference and c-myc gene
silencing by siRNAs in human cells", THE EMBO JOURNAL, vol. 28, no. 12, 17 June 2009
(2009-06-17) , pages 1708-1719, XP055009047, ISSN: 0261-4189, DOI: 10.1038/emboj.2009.139
- KALANTARI ROYA ET AL: "Regulation of mammalian transcription and splicing by Nuclear
RNAi", NUCLEIC ACIDS RESEARCH, vol. 44, no. 2, January 2016 (2016-01), pages 524-537,
ISSN: 0305-1048(print)
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