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EP 2 590 957 A2

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(88) Date of publication A3: 01.03.2012 (43) Date of publication: 15.05.2013 Bulletin 2013/20 (21) Application number: 11746618.5 (22) Date of filing: 01.07.2011

(51) International Patent Classification (IPC):  C07D 285/08(2006.01) C07D 401/12(2006.01) A61K 31/433(2006.01) A61K 31/501(2006.01) C07D 285/135(2006.01) C07D 417/12(2006.01) A61K 31/4427(2006.01) A61P 25/04(2006.01) (86) International application number: PCT/IB2011/052920 (87) International publication number: WO 2012/004714 (12.01.2012 Gazette 2012/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 09.07.2010 US 362919 P (71) Applicants: Pfizer Limited Sandwich, Kent CT13 9NJ (GB) Icagen, Inc. Durham, NC 27703 (US)

(72) Inventors: GREENER, Benjamin Scott Sandwich Kent CT13 9NJ (GB) MARRON, Brian Edward Durham North Carolina 27703 (US) MILLAN, David Simon Sandwich Kent CT13 9NJ (GB) RAWSON, David James Sandwich Kent CT13 9NJ (GB) STORER, Robert Ian Sandwich Kent CT13 9NJ (GB) SWAIN, Nigel Alan Sandwich Kent CT13 9NJ (GB) (74) Representative: Pfizer  European Patent Department 23-25 avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)