(19)
(11) EP 2 593 142 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
26.12.2018 Bulletin 2018/52

(45) Mention of the grant of the patent:
10.10.2018 Bulletin 2018/41

(21) Application number: 11745833.1

(22) Date of filing: 11.07.2011
(51) International Patent Classification (IPC): 
C07K 16/28(2006.01)
A61K 47/00(2006.01)
A61P 35/00(2006.01)
(86) International application number:
PCT/IB2011/053092
(87) International publication number:
WO 2012/007896 (19.01.2012 Gazette 2012/03)

(54)

MULTIFUNCTIONAL ANTIBODY CONJUGATES

MULTIFUNKTIONELLE ANTIKĂ–RPERKONJUGATE

CONJUGUÉS D'ANTICORPS MULTIFONCTIONNELS


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 12.07.2010 US 363507 P

(43) Date of publication of application:
22.05.2013 Bulletin 2013/21

(73) Proprietor: Pfizer Healthcare Ireland
Dublin 24 (IE)

(72) Inventors:
  • BHAT, Abhijit Suresh
    San Diego, CA 92121 (US)
  • BRADSHAW, Curt William
    San Diego, CA 92127 (US)
  • LAURENT, Olivier Alexandre
    San Diego, CA 92121 (US)
  • PRESTON, Richard Ryan
    San Diego, CA 92121 (US)
  • TUMELTY, David
    San Diego, CA 92121 (US)
  • WOOD, Lauren Diane
    San Diego, CA 92121 (US)
  • YU, Wei Hong
    San Diego, CA 92121 (US)
  • LEE, Alice
    San Diego, CA 92121 (US)

(74) Representative: Pfizer 
European Patent Department 23-25 avenue du Docteur Lannelongue
75668 Paris Cedex 14
75668 Paris Cedex 14 (FR)


(56) References cited: : 
WO-A1-2009/136352
WO-A2-2008/056346
   
  • HUANG HANHUA ET AL: "Angiopoietin-2 antagonistic CovX-BodyTM inhibits tumor growth and reduces microvessel density", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 48, 1 April 2007 (2007-04-01), page 509, XP001536926, ISSN: 0197-016X
  • Rosen et al.: "First-in-human dose-escalation safety and PK trial of a novel intravenous humanized monoclonal CovX body inhibiting angiopoietin 2. Abstract 2524", Internet Journal of Clinical Oncology, vol. 28, no. 15 20 May 2010 (2010-05-20), XP002663786, Retrieved from the Internet: URL:http://meeting.ascopubs.org/cgi/conten t/abstract/28/15_suppl/2524?sid=e726c48d-a 861-4011-b449-b0f58a4956ba [retrieved on 2011-11-17]
  • V. R. DOPPALAPUDI ET AL: "Chemical generation of bispecific antibodies", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 107, no. 52, 28 December 2010 (2010-12-28), pages 22611-22616, XP55003821, ISSN: 0027-8424, DOI: 10.1073/pnas.1016478108
  • HUANG HANHUA ET AL: "Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 MAR 2011 LNKD- PUBMED:21233403, vol. 17, no. 5, 1 March 2011 (2011-03-01), pages 1001-1011, XP002663787, ISSN: 1078-0432
  • HERBST ROY S ET AL: "Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, vol. 27, no. 21, 20 July 2009 (2009-07-20) , pages 3557-3565, XP002613992, ISSN: 0732-183X, DOI: 10.1200/JCO.2008.19.6683
  • HUANG HANHUA ET AL: "Targeting the ANGPT-TIE2 pathway in malignancy.", NATURE REVIEWS. CANCER AUG 2010 LNKD- PUBMED:20651738, vol. 10, no. 8, August 2010 (2010-08), pages 575-585, XP002663788, ISSN: 1474-1768
   
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