(19)

(11)

EP 2 603 288 A1

(12)

(43) Date of publication: 19.06.2013 Bulletin 2013/25 (21) Application number: 10747433.0 (22) Date of filing: 11.08.2010

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) A61K 9/20(2006.01) A61K 31/506(2006.01) A61K 9/16(2006.01) (86) International application number: PCT/EP2010/005214 (87) International publication number: WO 2012/019633 (16.02.2012 Gazette 2012/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (71) Applicant: Synthon BV 6545 CM Nijmegen (NL)	(72) Inventor: VAN DEN HEUVEL, Dennie Johan Marijn NL-6642 DH Beuningen (NL) (74) Representative: van der Sterren-Mol, Josephine et al Synthon BV IP Research P.O. Box 7071 6503 GN Nijmegen 6503 GN Nijmegen (NL)