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EP 2 614 369 A2

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(88) Date of publication A3: 07.06.2012 (43) Date of publication: 17.07.2013 Bulletin 2013/29 (21) Application number: 11824247.8 (22) Date of filing: 12.09.2011

(51) International Patent Classification (IPC):  G01N 33/50(2006.01) G01N 33/53(2006.01) C07D 473/34(2006.01) G01N 33/68(2006.01) A61K 38/17(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2011/051258 (87) International publication number: WO 2012/034132 (15.03.2012 Gazette 2012/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 10.09.2010 US 381684 P (71) Applicant: Epizyme, Inc. Cambridge, MA 02139 (US)

(72) Inventors: COPELAND, Robert Allen Lexington, MA 02421 (US) RICHON, Victoria Marie Wellesley, MA 02481 (US) SCOTT, Margaret Davis Beverly, MA 01915 (US) SNEERINGER, Christopher John San Francisco, CA 94110 (US) KUNTZ, Kevin Wayne Woburn, MA 01801 (US) KNUTSON, Sarah Kathleen Cambridge, MA 02138 (US) POLLOCK, Roy Macfarlane Medford, MA 02155 (US) (74) Representative: Mintz Levin Cohn Ferris Glovsky and Popeo LLP  Alder Castle 10 Noble Street London EC2V 7JX London EC2V 7JX (GB)