(19)

(11)

EP 2 615 113 A3

(12)	EUROPEAN PATENT APPLICATION

(88) Date of publication A3: 13.11.2013 Bulletin 2013/46 (43) Date of publication A2: 17.07.2013 Bulletin 2013/29 (21) Application number: 13151343.4 (22) Date of filing: 22.08.2008

(51) International Patent Classification (IPC):  C07K 16/40(2006.01) A61K 39/395(2006.01) A61K 31/22(2006.01) A61K 31/40(2006.01) A61K 31/44(2006.01) A61K 31/505(2006.01) A61P 3/06(2006.01) A61K 45/06(2006.01) A61K 31/366(2006.01) A61K 31/405(2006.01) A61K 31/47(2006.01) A61K 31/66(2006.01)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 04.08.2008 US 86133 P (62) Application number of the earlier application in accordance with Art. 76 EPC: 08798550.3 / 2215124 (71) Applicant: Amgen Inc. Thousand Oaks, CA 91320-1799 (US)

(72) Inventors: Jackson, Simon Mark San Carlos, CA 94070 (US) Walker, Nigel Pelham Clinton Burlingame, CA 94010-6033 (US) Piper, Derek Evan Santa Clara, CA 95051 (US) Shan, Bei Redwood City, CA 94065 (US) Shen, Wenyan Wayne, PA 19087 (US) Chan, Joyce Chi Yee San Francisco, CA 94112 (US) King, Chadwick Terence North Vancouver, British Columbia V7L 3T5 (CA) Ketchem, Randal Robert Snohomish, WA 98296 (US) Mehlin, Christopher Seattle, WA 98107 (US) Carabeo, Teresa Arazas New York, NY 10003-2489 (US) Cao, Qiong Burlingame, CA 94010 (US) (74) Representative: Dörries, Hans Ulrich  df-mp Fünf Höfe Theatinerstrasse 16 80333 München 80333 München (DE)