(19)

(11)

EP 2 616 082 A2

(12)

(88) Date of publication A3: 28.06.2012 (43) Date of publication: 24.07.2013 Bulletin 2013/30 (21) Application number: 11826075.1 (22) Date of filing: 19.09.2011

(51) International Patent Classification (IPC):  A61K 31/713(2006.01) A61P 11/00(2006.01) A61P 13/12(2006.01) A61P 1/16(2006.01) (86) International application number: PCT/US2011/052128 (87) International publication number: WO 2012/037547 (22.03.2012 Gazette 2012/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 17.09.2010 US 384076 P (71) Applicants: Mount Sinai School Of Medicine New York, New York 10029 (US) Hernandez-Gea, Virginia New York, New York 10029 (US)	(72) Inventors: HERNANDEZ-GEA, Virginia New York New York 10029 (US) FRIEDMAN, Scott L. New York New York 10025 (US) GHIASSI-NEJAD, Zahra New York New York 10128 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser  Leopoldstrasse 4 80802 München 80802 München (DE)