(19)

(11)

EP 2 616 478 A2

(12)

(88) Date of publication A3: 05.07.2012 (43) Date of publication: 24.07.2013 Bulletin 2013/30 (21) Application number: 11826047.0 (22) Date of filing: 16.09.2011

(51) International Patent Classification (IPC):  C07K 7/08(2006.01) A61K 38/10(2006.01) C07D 473/18(2006.01) C08B 3/06(2006.01) C07K 7/06(2006.01) A61K 38/08(2006.01) C07D 401/12(2006.01) A61P 31/20(2006.01) (86) International application number: PCT/US2011/052002 (87) International publication number: WO 2012/037498 (22.03.2012 Gazette 2012/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 16.09.2010 US 383520 P (71) Applicant: University Of Illinois Chicago, Illinois 60612 (US)	(72) Inventors: SHUKLA, Deepak Orland Park Illinois 60462 (US) TIWARI, Vaibhav Chicago Illinois 60612 (US) (74) Representative: Kremer, Simon Mark  Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)