COMBINATIONS OF 4-(CYCLOPROPYLAMINO)-2-(4-(4-(ETHYLSULFONYL)PIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDINE-5-CARBOXAMIDE AND FLUDARABINE - Patent 2621489

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EP 2 621 489 A1

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(43)	Date of publication:
	07.08.2013 Bulletin 2013/32

(21)	Application number: 11770292.8

(22)	Date of filing: 30.09.2011

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International Patent Classification (IPC):

A61K 31/4192^(2006.01)
A61P 35/00^(2006.01)

A61K 31/7076^(2006.01)

(86)	International application number:
	PCT/US2011/054373

(87)	International publication number:
	WO 2012/045020 (05.04.2012 Gazette 2012/14)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

03.12.2010 US 419728 P
30.09.2010 US 388570 P

(71)	Applicant: Portola Pharmaceuticals, Inc.
	South San Francisco, California 94080 (US)

(72)	Inventors:
	SINHA, Uma San Francisco California 94127 (US) PANDEY, Anjali Fremont California 94555 (US)

(74)	Representative: Sexton, Jane Helen
	J A Kemp 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)

(54)	COMBINATIONS OF 4-(CYCLOPROPYLAMINO)-2-(4-(4-(ETHYLSULFONYL)PIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDINE-5-CARBOXAMIDE AND FLUDARABINE