(19)
(11) EP 2 621 531 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
18.01.2017 Bulletin 2017/03

(45) Mention of the grant of the patent:
30.11.2016 Bulletin 2016/48

(21) Application number: 11761360.4

(22) Date of filing: 26.09.2011
(51) International Patent Classification (IPC): 
A61K 39/395(2006.01)
A61K 38/07(2006.01)
A61K 31/454(2006.01)
C07K 16/28(2006.01)
A61K 31/69(2006.01)
A61K 38/05(2006.01)
A61K 45/06(2006.01)
C07K 16/30(2006.01)
A61P 35/00(2006.01)
(86) International application number:
PCT/EP2011/066648
(87) International publication number:
WO 2012/041800 (05.04.2012 Gazette 2012/14)

(54)

ANTI-CD38 ANTIBODY AND LENALIDOMIDE OR BORTEZOMIB FOR THE TREATMENT OF MULTIPLE MYELOMA AND NHL

ANTI-CD38 ANTIKÖRPER UND LENALIDOMID ODER BORTEZOMIB ZUR BEHANDLUNG VON MULTIPLEM MYELOM UND NHL

ANTICORPS ANTI-CD38 ET LÉNALIDOMIDE OR BORTEZOMIB POUR LE TRAITEMENT DU MYELOMA MULTIPLE OU LYMPHOMES NON HODGKINIENS


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 17.05.2011 US 201161486814 P
29.03.2011 US 201161468607 P
31.01.2011 US 201161437696 P
27.09.2010 US 386619 P
27.09.2010 EP 10180485

(43) Date of publication of application:
07.08.2013 Bulletin 2013/32

(73) Proprietor: MorphoSys AG
82152 Martinsried/Planegg (DE)

(72) Inventors:
  • ROJKJAER, Lisa
    8908 Hedingen (CH)
  • BOXHAMMER, Rainer
    85653 Aying (DE)
  • ENDELL, Jan
    80333 München (DE)
  • WINDERLICH, Mark
    81371 München (DE)
  • SAMUELSSON, Christofer
    83607 Holzkirchen (DE)

(74) Representative: Hutter, Bernd et al
MorphoSys AG Lena-Christ-Straße 48
82152 Martinsried/Planegg
82152 Martinsried/Planegg (DE)


(56) References cited: : 
WO-A2-2007/042309
WO-A2-2008/037257
   
  • WIERNIK PETER H: "Treatment of hematologic neoplasms with new immunomodulatory drugs (IMiDs).", CURRENT TREATMENT OPTIONS IN ONCOLOGY APR 2009 LNKD- PUBMED:19016330, vol. 10, no. 1-2, April 2009 (2009-04), pages 1-15, XP009145844, ISSN: 1534-6277
  • STEVENSON G T: "CD38 as a therapeutic target", MOLECULAR MEDICINE 200611 US LNKD- DOI:10.2119/2006-00082.STEVENSON, vol. 12, no. 11-12, November 2006 (2006-11), pages 345-346, XP009145827, ISSN: 1076-1551
  • RICHARDS TIFFANY ET AL: "Advances in treatment for relapses and refractory multiple myeloma", MEDICAL ONCOLOGY (TOTOWA), vol. 27, no. Suppl. 1, June 2010 (2010-06) , pages 25-42, XP009145832, ISSN: 1357-0560
  • LAPALOMBELLA ROSA ET AL: "Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 112, no. 13, 15 December 2008 (2008-12-15), pages 5180-5189, XP009145765, ISSN: 0006-4971
  • GHOSH NILANJAN ET AL: "Bortezomib and Thalidomide, a Steroid Free Regimen in Newly Diagnosed Patients with Multiple Myeloma", BLOOD, vol. 114, no. 22, November 2009 (2009-11), page 1119, XP009145845, & 51ST ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; NEW ORLEANS, LA, USA; DECEMBER 05 -08, 2009
  • VAN DER VEER MICHAEL S ET AL: "Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab.", HAEMATOLOGICA FEB 2011 LNKD- PUBMED:21109694, vol. 96, no. 2, February 2011 (2011-02), pages 284-290, XP009145823, ISSN: 1592-8721
   
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