(19)
(11) EP 2 621 931 A1

(12)

(43) Date of publication:
07.08.2013 Bulletin 2013/32

(21) Application number: 11827912.4

(22) Date of filing: 28.09.2011
(51) International Patent Classification (IPC): 
C07D 498/04(2006.01)
C07D 471/04(2006.01)
A61K 31/4985(2006.01)
A61P 31/14(2006.01)
 C07D 487/04(2006.01)
A61K 31/5365(2006.01)
A61K 31/437(2006.01)
(86) International application number:
PCT/CN2011/001638
(87) International publication number:
WO 2012/041014 (05.04.2012 Gazette 2012/14)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 23.12.2010 US 201061426724 P
29.09.2010 WO PCT/CN2010/077493

(71) Applicant: Merck Sharp & Dohme Corp.
Rahway, NJ 07065-0907 (US)

(72) Inventors:
  • KOZLOWSKI, Joseph A.
    Kenilworth, New Jersey 07033 (US)
  • ROSENBLUM, Stuart B.
    Kenilworth, New Jersey 07033 (US)
  • COBURN, Craig A.
    West Point, Pennsylvania 19486 (US)
  • SHANKAR, Bandarpalle, B.
    Kenilworth, New Jersey 07033 (US)
  • ANILKUMAR, G., Nair
    Kenilworth, New Jersey 07033 (US)
  • CHEN, Lei
    Kenilworth, New Jersey 07033 (US)
  • DWYER, Michael, P.
    Kenilworth, New Jersey 07033 (US)
  • JIANG, Yueheng
    Kenilworth, New Jersey 07033 (US)
  • KEERTIKAR, Kartik, M.
    Kenilworth, New Jersey 07033 (US)
  • LAVEY, Brian, J.
    Kenilworth, New Jersey 07033 (US)
  • SELYUTIN, Oleg, B.
    Kenilworth, New Jersey 07033 (US)
  • TONG, Ling
    Kenilworth, New Jersey 07033 (US)
  • WONG, Michael
    Kenilworth, New Jersey 07033 (US)
  • YANG, De-Yi
    Kenilworth, New Jersey 07033 (US)
  • YU, Wensheng
    Kenilworth, New Jersey 07033 (US)
  • ZHOU, Guowei
    Kenilworth, New Jersey 07033 (US)
  • WU, Hao
    Shanghai 200131 (CN)
  • HU, Bin
    Shanghai 200131 (CN)
  • ZHONG, Bin
    Shanghai 200131 (CN)
  • SUN, Fei
    Shanghai 200131 (CN)
  • JI, Tao
    Shanghai 200131 (CN)
  • SHEN, Changmao
    Shanghai 200131 (CN)
  • RIZVI, Razia
    Rahway, New Jersey 07065-0907 (US)
  • ZENG, Qingbei
    Rahway, New Jersey 07065-0907 (US)

(74) Representative: Jaap, David Robert et al
Merck & Co., Inc. Patent Department Hertford Road
Hoddesdon, Herts EN11 9BU
Hoddesdon, Herts EN11 9BU (GB)

   


(54) TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION