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EP 2 621 932 A1

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(43) Date of publication: 07.08.2013 Bulletin 2013/32 (21) Application number: 11828123.7 (22) Date of filing: 28.09.2011

(51) International Patent Classification (IPC):  C07D 498/04(2006.01) C07D 471/04(2006.01) C07D 491/22(2006.01) A61K 31/5365(2006.01) A61K 31/437(2006.01) C07D 487/04(2006.01) C07D 471/22(2006.01) C07D 493/22(2006.01) A61K 31/4985(2006.01) A61P 31/14(2006.01) (86) International application number: PCT/CN2011/080270 (87) International publication number: WO 2012/041227 (05.04.2012 Gazette 2012/14)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 23.12.2010 US 201061426738 P 29.09.2010 WO PCT/CN2010/077498 (71) Applicant: Merck Sharp & Dohme Corp. Rahway, NJ 07065-0907 (US)

(72) Inventors: DWYER, Michael P New Jersey 07033 (US) KEERTIKAR, Kartik M New Jersey 07033 (US) COBURN, Craig A Pennsylvania 19486 (US) WU, Hao Shanghai 200131 (CN) HU, Bin Shanghai 200131 (CN) ZHONG, Bin Shanghai 200131 (CN) ZHANG, Chengren Shanghai 200131 (CN) DAN, Zhigang Shanghai 200131 (CN) TONG, Ling New Jersey 07033 (US) YU, Wensheng New Jersey 07033 (US) (74) Representative: Jaap, David Robert et al Merck & Co., Inc. Patent Department Hertford Road Hoddesdon, Herts EN11 9BU Hoddesdon, Herts EN11 9BU (GB)