(19)

(11)

EP 2 629 803 A2

(12)

(88) Date of publication A3: 09.08.2012 (43) Date of publication: 28.08.2013 Bulletin 2013/35 (21) Application number: 11835157.6 (22) Date of filing: 20.10.2011

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A01N 63/00(2006.01) (86) International application number: PCT/US2011/057129 (87) International publication number: WO 2012/054747 (26.04.2012 Gazette 2012/17)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 20.10.2010 US 394950 P (71) Applicant: Mount Sinai School Of Medicine New York, New York 10029 (US)	(72) Inventor: CHEN, Shu-Hsia New York New York 10025 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser  Leopoldstrasse 4 80802 München 80802 München (DE)