(19)
(11) EP 2 630 251 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
10.06.2015 Bulletin 2015/24

(45) Mention of the grant of the patent:
29.04.2015 Bulletin 2015/18

(21) Application number: 11776819.2

(22) Date of filing: 18.10.2011
(51) International Patent Classification (IPC): 
C12Q 1/48(2006.01)
 G01N 33/68(2006.01)
(86) International application number:
PCT/GB2011/001497
(87) International publication number:
WO 2012/052711 (26.04.2012 Gazette 2012/17)

(54)

METHOD FOR IDENTIFYING ACTIVATION OF TRANSFERASES.

VERFAHREN ZUR IDENTIFIZIERUNG DER AKTIVIERUNG VON TRANSFERASEN

PROCÉDÉ D'IDENTIFICATION D'ACTIVATION DE TRANSFÉRASES

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 20.10.2010 GB 201017721

(43) Date of publication of application:
28.08.2013 Bulletin 2013/35

(73) Proprietor: hVIVO Services Limited
London E1 2AX (GB)

(72) Inventors:
  • RODRIGUEZ CUTILLAS, Pedro
    Charterhouse Square London EC1M 6BQ (GB)
  • VANHAESEBROECK, Bart
    Charterhouse Square London EC1M 6BQ (GB)
  • BELTRAN, Luisa, Marie
    Charterhouse Square London EC1M 6BQ (GB)

(74) Representative: Mintz Levin Cohn Ferris Glovsky and Popeo LLP 
Alder Castle 10 Noble Street
London EC2V 7JX
London EC2V 7JX (GB)


(56) References cited: : 
WO-A2-2010/040024
   
  • KAZUISHI KUBOTA ET AL: "Sensitive multiplexed analysis of kinase activities and activity-based kinase identification", NATURE BIOTECHNOLOGY, vol. 27, no. 10, 1 October 2009 (2009-10-01), pages 933-940, XP55018815, ISSN: 1087-0156, DOI: 10.1038/nbt.1566
  • WEIFENG LUO ET AL: "Global Impact of Oncogenic Src on a Phosphotyrosine Proteome", JOURNAL OF PROTEOME RESEARCH, vol. 7, no. 8, 1 August 2008 (2008-08-01), pages 3447-3460, XP55019066, ISSN: 1535-3893, DOI: 10.1021/pr800187n
  • P. R. CUTILLAS: "Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 103, no. 24, 1 June 2006 (2006-06-01) , pages 8959-8964, XP55018814, ISSN: 0027-8424, DOI: 10.1073/pnas.0602101103
  • OLSEN JESPER V ET AL: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks", CELL, CELL PRESS, US, vol. 127, no. 3, 3 November 2006 (2006-11-03), pages 635-648, XP009091121, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2006.09.026
  • MARIA P. ALCOLEA ET AL: "Increased Confidence in Large-Scale Phosphoproteomics Data by Complementary Mass Spectrometric Techniques and Matching of Phosphopeptide Data Sets", JOURNAL OF PROTEOME RESEARCH, vol. 8, no. 8, 7 August 2009 (2009-08-07), pages 3808-3815, XP55018854, ISSN: 1535-3893, DOI: 10.1021/pr800955n
  • PEDRO R. CUTILLAS ET AL: "Biological signalling activity measurements using mass spectrometry", BIOCHEMICAL JOURNAL, vol. 434, no. 2, 1 March 2011 (2011-03-01) , pages 189-199, XP55018818, ISSN: 0264-6021, DOI: 10.1042/BJ20101974
   
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