(19)
(11) EP 2 630 971 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
13.12.2017 Bulletin 2017/50

(45) Mention of the grant of the patent:
23.08.2017 Bulletin 2017/34

(21) Application number: 12001136.6

(22) Date of filing: 21.02.2012
(51) International Patent Classification (IPC): 
A61K 47/64(2017.01)
A61K 31/704(2006.01)
A61K 31/519(2006.01)
A61P 35/00(2006.01)

(54)

Combinations of albumin-based drug delivery systems

Kombinationen aus Arzneimittelabgabesystemen auf Albuminbasis

Combinaisons de systèmes d'administration de médicaments à base d'albumine


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(43) Date of publication of application:
28.08.2013 Bulletin 2013/35

(73) Proprietor: Vergell Medical S.A.
1204 Geneva (CH)

(72) Inventors:
  • Kratz, Felix
    79238 Ehrenkirchen (DE)
  • Warnecke, André
    79117 Freiburg (DE)

(74) Representative: Müller-Boré & Partner Patentanwälte PartG mbB 
Friedenheimer Brücke 21
80639 München
80639 München (DE)


(56) References cited: : 
EP-A1- 1 419 788
US-A1- 2004 063 635
   
  • DESAI N ET AL: "Antitumor activity, and antiangiogenic activity of nanoparticle albumin-bound nab-rapamycin in combination with nab-paclitaxel", CANCER RESEARCH, vol. 69, no. 2, Suppl. 1 January 2009 (2009-01), XP002678704, & 31ST ANNUAL SAN ANTONIO BREAST CANCER SYMPOSIUM; SAN ANTONIO, TX, USA; DECEMBER 10 -14, 2008 ISSN: 0008-5472 Retrieved from the Internet: URL:http://cancerres.aacrjournals.org/cgi/ content/meeting_abstract/69/2_MeetingAbstr acts/3125 [retrieved on 2012-06-26]
  • CHARLOTTE FOWLER J ET AL: "Dual-isotope lymphoscintigraphy using albumin nanocolloid differentially labeled with 111In and 99mTc", ACTA ONCOLOGICA, vol. 46, no. 1, 1 January 2007 (2007-01-01), pages 105-110, XP002631492, INFORMA HEALTHCARE, LONDON, GB ISSN: 0284-186X, DOI: 10.1080/02841860600635854
  • FELIX KRATZ: "DOXO-EMCH (INNO-206): the first albumin-binding prodrug of doxorubicin to enter clinical trials", EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 16, no. 6, 1 June 2007 (2007-06-01), pages 855-866, XP055031139, ISSN: 1354-3784, DOI: 10.1517/13543784.16.6.855
  • ANDRÉ WARNECKE ET AL: "Synthesis, Cleavage Profile, and Antitumor Efficacy of an Albumin-Binding Prodrug of Methotrexate that is Cleaved by Plasmin and Cathepsin B", ARCHIV DER PHARMAZIE, vol. 340, no. 8, 1 August 2007 (2007-08-01), pages 389-395, XP055031081, ISSN: 0365-6233, DOI: 10.1002/ardp.200700025
  • ELSADEK B ET AL: "Development of a novel prodrug of paclitaxel that is cleaved by prostate-specific antigen: An in vitro and in vivo evaluation study", EUROPEAN JOURNAL OF CANCER, vol. 46, no. 18, 1 December 2010 (2010-12-01), pages 3434-3444, XP027546744, PERGAMON PRESS, OXFORD, GB ISSN: 0959-8049 [retrieved on 2010-12-01]
  • BAKHEET ELSADEK ET AL: "Impact of albumin on drug delivery - New applications on the horizon", JOURNAL OF CONTROLLED RELEASE, vol. 157, no. 1, 1 January 2012 (2012-01-01), pages 4-28, XP055031206, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2011.09.069
  • Björn Schmid ET AL: "Albumin-Binding Prodrugs of Camptothecin and Doxorubicin with an Ala-Leu-Ala-Leu-Linker That Are Cleaved by Cathepsin B: Synthesis and Antitumor Efficacy", Bioconjugate Chemistry, vol. 18, no. 3, 1 May 2007 (2007-05-01), pages 702-716, XP055076344, ISSN: 1043-1802, DOI: 10.1021/bc0602735
  • CHUNG D E ET AL: "Development of a novel albumin-binding prodrug that is cleaved by urokinase-type-plasminogen activator (uPA)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 16, no. 19, 1 October 2006 (2006-10-01), pages 5157-5163, XP027966605, ISSN: 0960-894X [retrieved on 2006-10-01]
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).