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(11)

EP 2 632 263 A1

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(43) Date of publication: 04.09.2013 Bulletin 2013/36 (21) Application number: 11836930.5 (22) Date of filing: 25.10.2011

(51) International Patent Classification (IPC):  A01N 43/40(2006.01) A61K 31/445(2006.01) A61K 31/425(2006.01) (86) International application number: PCT/US2011/057558 (87) International publication number: WO 2012/058174 (03.05.2012 Gazette 2012/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 29.10.2010 US 408179 P (71) Applicant: Merck Sharp & Dohme Corp. Rahway, NJ 07065-0907 (US)

(72) Inventors: TSUI, Hon-Chung Kenilworth New Jersey 07033 (US) PALIWAL, Sunil Kenilworth New Jersey 07033 (US) GAO, Xiaolei Kenilworth New Jersey 07033 (US) KIM, Hyunjin, M. Kenilworth New Jersey 07033 (US) DOLL, Ronald, J. Convent Station New Jersey 07960 (US) (74) Representative: Hussain, Deeba  Merck & Co., Inc. Patent Department Hertford Road Hoddesdon Hertfordshire EN11 9BU Hoddesdon Hertfordshire EN11 9BU (GB)