(19)

(11)

EP 2 637 571 A2

(12)

(88) Date of publication A3: 02.08.2012 (43) Date of publication: 18.09.2013 Bulletin 2013/38 (21) Application number: 11840646.1 (22) Date of filing: 11.11.2011

(51) International Patent Classification (IPC):  A61B 8/14(2006.01) A61N 7/00(2006.01) (86) International application number: PCT/US2011/060362 (87) International publication number: WO 2012/065058 (18.05.2012 Gazette 2012/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 11.11.2010 US 412589 P (71) Applicant: The Johns Hopkins University Baltimore, MD 21218 (US)	(72) Inventors: STOIANOVICI, Dan Reisterstown, Maryland 21136 (US) PETRISOR, Doru Towson, Maryland 21286 (US) SCHAFER, Felix Baltimore, Maryland 21224 (US) KIM, Chunwoo Baltimore, Maryland 21224 (US) HAN, Misop West Friendship, Maryland 21794 (US) (74) Representative: Rutherford, Claire et al Murgitroyd & Company Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)