(19)

(11)

EP 2 638 018 A1

(12)

(43) Date of publication: 18.09.2013 Bulletin 2013/38 (21) Application number: 11781515.9 (22) Date of filing: 07.11.2011

(51) International Patent Classification (IPC):  C07D 239/42(2006.01) A61K 31/505(2006.01) C07D 401/14(2006.01) C07D 405/14(2006.01) C07D 413/14(2006.01) C07D 417/14(2006.01) C07D 403/12(2006.01) A61K 31/506(2006.01) C07D 403/14(2006.01) C07D 409/12(2006.01) C07D 417/12(2006.01) (86) International application number: PCT/EP2011/069553 (87) International publication number: WO 2012/062704 (18.05.2012 Gazette 2012/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 09.11.2010 EP 10190460 (71) Applicant: Cellzome Limited Little Chesterford Cambridgeshire CB10 1XL (GB)	(72) Inventors: ELLARD, Katie Royston Herts SG8 5HQ (GB) MAJOR, Jeremy Brentford, Middlesex TW89GS (GB) JONES, Alison CB4 8SA (GB) LYNCH, Rosemary Cambridge CB1 3SX (GB) RAMSDEN, Nigel Herts SG8 7QP (GB) (74) Representative: Büchel, Edwin  Isenbruck Bösl Hörschler LLP Patentanwälte Eastsite One Seckenheimer Landstraße 4 68163 Mannheim 68163 Mannheim (DE)