| (19) |
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(11) |
EP 2 639 307 A8 |
| (12) |
CORRECTED EUROPEAN PATENT APPLICATION |
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Note: Bibliography reflects the latest situation |
| (15) |
Correction information: |
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Corrected version no 1 (W1 A3) |
| (48) |
Corrigendum issued on: |
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30.04.2014 Bulletin 2014/18 |
| (88) |
Date of publication A3: |
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05.02.2014 Bulletin 2014/06 |
| (43) |
Date of publication: |
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18.09.2013 Bulletin 2013/38 |
| (22) |
Date of filing: 28.07.2011 |
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| (51) |
International Patent Classification (IPC):
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| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
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Designated Extension States: |
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BA ME |
| (30) |
Priority: |
03.08.2010 JP 2010174915
13.10.2010 JP 2010230806
02.12.2010 JP 2010269823
08.07.2011 JP 2011152381
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| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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11748250.5 / 2436767 |
| (71) |
Applicant: Bonac Corporation |
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Kurume-shi, Fukuoka 839-0861 (JP) |
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| (72) |
Inventors: |
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- Ohgi, Tadaaki
Kurume-shi
Fukuoka 839-0861 (JP)
- Hayashi, Hirotake
Kurume-shi
Fukuoka 839-0861 (JP)
- Shirohzu, Hisao
Kurume-shi
Fukuoka 839-0861 (JP)
- Hamasaki, Tomohiro
Kurume-shi
Fukuoka 839-0861 (JP)
- Itoh, Akihiro
Kurume-shi
Fukuoka 839-0861 (JP)
- Suzuki, Hiroshi
Kurume-shi
Fukuoka 839-0861 (JP)
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| (74) |
Representative: Woods, Geoffrey Corlett |
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J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB) |
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| (54) |
Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
(57) Provided is a novel nucleic acid molecule that can be produced easily and efficiently
and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded
nucleic acid molecule including an expression inhibitory sequence that inhibits expression
of a target gene. The single-stranded nucleic acid molecule includes: a region (X);
a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between
the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At
least one of the regions (X) and (Xc) includes the expression inhibitory sequence.
The linker region (Lx) has a non-nucleotide structure including at least one of a
pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded
nucleic acid molecule, it is possible to inhibit the expression of the target gene.