(19)

(11)

EP 2 640 369 A1

(12)

(43) Date of publication: 25.09.2013 Bulletin 2013/39 (21) Application number: 11784634.5 (22) Date of filing: 14.11.2011

(51) International Patent Classification (IPC):  A61K 31/105(2006.01) A61K 31/713(2006.01) A61K 31/519(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/EP2011/070008 (87) International publication number: WO 2012/065935 (24.05.2012 Gazette 2012/21)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 17.11.2010 US 414671 P 12.08.2011 US 201161523062 P (71) Applicant: F.Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: HOEFLICH, Klaus P. San Mateo, California 94401 (US) KOEPPEN, Hartmut South San Francisco, California 94080 (US) ONG, Christy C. South San Francisco, California 94080 (US) (74) Representative: Schirlin, Julien  F. Hoffmann-La Roche AG CLP - Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)