(19)

(11)

EP 2 640 704 A1

(12)

(43) Date of publication: 25.09.2013 Bulletin 2013/39 (21) Application number: 11785266.5 (22) Date of filing: 11.11.2011

(51) International Patent Classification (IPC):  C07D 217/06(2006.01) C07D 405/12(2006.01) C07D 409/14(2006.01) C07D 471/04(2006.01) A61K 31/496(2006.01) A61K 31/4725(2006.01) A61P 37/00(2006.01) A61P 35/00(2006.01) C07D 401/12(2006.01) C07D 409/12(2006.01) C07D 413/12(2006.01) A61K 31/4375(2006.01) A61K 31/472(2006.01) A61P 29/00(2006.01) A61P 9/00(2006.01) (86) International application number: PCT/US2011/060411 (87) International publication number: WO 2012/067963 (24.05.2012 Gazette 2012/21)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 15.11.2010 US 413646 P (71) Applicant: Abbvie Inc. North Chicago, IL 60064 (US)

(72) Inventors: CURTIN, Michael L. Pleasant Prairie, Wisconsin 53158 (US) SORENSEN, Bryan K. Antioch, Illinois 60002 (US) HEYMAN, Howard R. Deerfield, Illinois 60015 (US) CLARK, Richard F. Gurnee, Illinois 60031 (US) MICHAELIDES, Michael Libertyville, Illinois 60048 (US) TSE, Chris Libertyville, Illinois 60048 (US) (74) Representative: Modiano, Micaela Nadia et al Modiano & Partners (DE) Thierschstrasse 11 80538 München 80538 München (DE)