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EP 2 640 715 A1

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(43) Date of publication: 25.09.2013 Bulletin 2013/39 (21) Application number: 11791704.7 (22) Date of filing: 17.11.2011

(51) International Patent Classification (IPC):  C07D 401/14(2006.01) A61K 31/506(2006.01) A61P 29/00(2006.01) C07D 413/14(2006.01) A61P 35/00(2006.01) A61P 37/00(2006.01) (86) International application number: PCT/US2011/061141 (87) International publication number: WO 2012/068343 (24.05.2012 Gazette 2012/21)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 17.11.2010 US 414558 P (71) Applicant: Amgen Inc. Thousand Oaks, California 91320-1799 (US)	(72) Inventors: CUSHING, Timothy D. Pacifica California 94044 (US) LOHMAN, Julia Winslow San Francisco California 94131 (US) SHIN, Youngsook Emeryville California 94608 (US) (74) Representative: HOFFMANN EITLE  Patent- und Rechtsanwälte Arabellastrasse 4 81925 München 81925 München (DE)