(19)

(11)

EP 2 648 735 A2

(12)

(88) Date of publication A3: 02.08.2012 (43) Date of publication: 16.10.2013 Bulletin 2013/42 (21) Application number: 11846821.4 (22) Date of filing: 06.12.2011

(51) International Patent Classification (IPC):  A61K 31/55(2006.01) A61K 31/4025(2006.01) A61K 38/05(2006.01) A61K 39/395(2006.01) A61P 17/02(2006.01) C07D 307/88(2006.01) C07F 9/6561(2006.01) C07K 14/82(2006.01) C12N 9/64(2006.01) A61K 31/365(2006.01) A61K 31/675(2006.01) A61K 38/57(2006.01) A61P 17/00(2006.01) C07C 237/22(2006.01) C07D 487/06(2006.01) C07K 5/00(2006.01) C07K 16/40(2006.01) (86) International application number: PCT/IB2011/003207 (87) International publication number: WO 2012/076985 (14.06.2012 Gazette 2012/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 06.12.2010 US 420230 P 03.06.2011 US 201161493265 P (71) Applicant: The University of British Columbia Vancouver, BC V6T 1Z3 (CA)	(72) Inventors: HIEBERT, Paul, R. Vancover BC V6J 1J4 (CA) KNIGHT, Darryl, A. Vancouver BC V5T 2W3 (CA) GRANVILLE, David, J. Port Coquitlam BC V3C 5Y1 (CA) BOIVIN, Wendy, A. Coquitlam BC V3B 5Y4 (CA) COOPER, Dawn, M. Vancouver BC V6K 4GB (CA) (74) Representative: van Kooij, Adriaan  Arnold & Siedsma Sweelickplein 1 2517 GK Den Haag 2517 GK Den Haag (NL)