(19)

(11)

EP 2 654 804 A1

(12)

(43) Date of publication: 30.10.2013 Bulletin 2013/44 (21) Application number: 11804897.4 (22) Date of filing: 19.12.2011

(51) International Patent Classification (IPC):  A61K 51/08(2006.01) C07K 14/31(2006.01) A61K 101/02(2006.01) (86) International application number: PCT/US2011/065794 (87) International publication number: WO 2012/087908 (28.06.2012 Gazette 2012/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 30.09.2011 US 201161541287 P 22.12.2010 US 975425 01.02.2011 US 201161438297 P 22.07.2011 US 201161510520 P (71) Applicant: GE Healthcare Limited Little Chalfont Buckinghamshire HP7 9NA (GB)

(72) Inventors: HISCOCK, Duncan Buckinghamshire HP7 9LL (GB) INDREVOLL, Bard N-0401 Oslo (NO) IVESON, Peter Buckinghamshire HP7 9LL (GB) GLASER, Matthias, Eberhard Buckinghamshire HP7 9LL (GB) BHALLA, Rajiv Buckinghamshire HP7 9LL (GB) WILSON, Anthony Waddesdon Buckinghamshire HP18 0LL (GB) (74) Representative: Canning, Lewis R. et al GE Healthcare Limited Pollards Wood Nightingales Lane Chalfont St Giles Buckinghamshire HP8 4SP Buckinghamshire HP8 4SP (GB)