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(11)

EP 2 658 574 A1

(12)

(43) Date of publication: 06.11.2013 Bulletin 2013/45 (21) Application number: 10861515.4 (22) Date of filing: 30.12.2010

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) A61K 47/30(2006.01) A61K 38/16(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2010/062515 (87) International publication number: WO 2012/091718 (05.07.2012 Gazette 2012/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (71) Applicant: Cedars-Sinai Medical Center Los Angeles, California 90048 (US)	(72) Inventors: INOUE, Satoshi Beverly Hills, CA 90210 (US) DING, Hui Los Angeles, CA 90034 (US) HOLLER, Eggehard Los Angeles, CA 90046 (US) BLACK, Keith Los Angeles, CA 90077 (US) LJUBIMOVA, Julia Studio City, CA 91604 (US) (74) Representative: Nederlandsch Octrooibureau  P.O. Box 29720 2502 LS The Hague 2502 LS The Hague (NL)