(19)
(11) EP 2 663 864 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
05.06.2019 Bulletin 2019/23

(45) Mention of the grant of the patent:
10.04.2019 Bulletin 2019/15

(21) Application number: 12734581.7

(22) Date of filing: 17.01.2012
(51) International Patent Classification (IPC): 
C12Q 1/686(2018.01)
C12Q 1/6869(2018.01)
(86) International application number:
PCT/US2012/021594
(87) International publication number:
WO 2012/097374 (19.07.2012 Gazette 2012/29)

(54)

IMMUNODIVERSITY ASSESSMENT METHOD AND ITS USE

IMMUNODIVERSITÄTS-SCHNELLBESTIMMUNGSVERFAHREN UND SEINE ANWENDUNG

PROCÉDÉ D'ÉVALUATION DE LA BIODIVERSITÉ ET SON UTILISATION


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 14.01.2011 US 201161432638 P

(43) Date of publication of application:
20.11.2013 Bulletin 2013/47

(73) Proprietor: iRepertoire, Inc.
Huntsville, AL 35806 (US)

(72) Inventor:
  • HAN, Jian
    Huntsville Alabama 35802 (US)

(74) Representative: Dehns 
St. Brides House 10 Salisbury Square
London EC4Y 8JD
London EC4Y 8JD (GB)


(56) References cited: : 
WO-A1-2011/139371
US-A1- 2006 160 153
US-A1- 2010 330 571
WO-A2-2004/033728
US-A1- 2010 021 896
US-A1- 2011 003 291
   
  • SCOTT D BOYD ET AL: "Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing", SCIENCE TRANSLATIONAL MEDICINE, vol. 1, no. 12, 23 December 2009 (2009-12-23), XP055076874,
  • GEORGE B. COHEN ET AL: "Clonotype Tracking of TCR Repertoires during Chronic Virus Infections", VIROLOGY, vol. 304, no. 2, 1 December 2002 (2002-12-01), pages 474-484, XP55275967, AMSTERDAM, NL ISSN: 0042-6822, DOI: 10.1006/viro.2002.1743
  • WANG ET AL.: 'High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets.' PROC NATL ACAD SCI USA vol. 107, no. 4, 26 January 2010, pages 1518 - 1523, XP055114155
  • LANGERAK A W ET AL: "Molecular and flow cytometric analysis of the Vbeta repertoire for clonality assessment in mature TCRalphabeta T-cell proliferations", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 98, no. 1, 1 July 2001 (2001-07-01), pages 165-173, XP002287368, ISSN: 0006-4971, DOI: 10.1182/BLOOD.V98.1.165
   
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