(19)

(11)

EP 2 667 876 A2

(12)

(88) Date of publication A3: 06.12.2012 (43) Date of publication: 04.12.2013 Bulletin 2013/49 (21) Application number: 11849491.3 (22) Date of filing: 15.12.2011

(51) International Patent Classification (IPC):  A61K 31/56(2006.01) (86) International application number: PCT/US2011/065298 (87) International publication number: WO 2012/083090 (21.06.2012 Gazette 2012/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 15.12.2010 US 423457 P (71) Applicant: Harbor BioSciences, Inc. San Diego, CA 92122 (US)	(72) Inventors: GE, Yu San Diego, CA 92129 (US) WHITE, Steven, K. San Diego, CA 92129 (US) HUANG, Yujin San Diego, CA 92131 (US) (74) Representative: Huenges, Martin  Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München 80335 München (DE)