(19)
(11) EP 2 668 209 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
11.08.2021 Bulletin 2021/32

(45) Mention of the grant of the patent:
30.12.2020 Bulletin 2020/53

(21) Application number: 12738907.0

(22) Date of filing: 20.01.2012
(51) International Patent Classification (IPC): 
C07K 16/28(2006.01)
A61P 35/00(2006.01)
A61K 39/395(2006.01)
C07K 16/46(2006.01)
(86) International application number:
PCT/CA2012/050034
(87) International publication number:
WO 2012/100346 (02.08.2012 Gazette 2012/31)

(54)

ANTIBODIES SELECTIVE FOR CELLS PRESENTING EGFR AT HIGH DENSITY

FÜR ZELLEN MIT EGFR BEI HOHER DICHTE SELEKTIVE ANTIKÖRPER

ANTICORPS SÉLECTIFS DES CELLULES PRÉSENTATRICES DES RÉCEPTEURS DE EGF À HAUTE DENSITÉ


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 24.01.2011 US 201161435510 P

(43) Date of publication of application:
04.12.2013 Bulletin 2013/49

(73) Proprietors:
  • Gilead Sciences, Inc.
    Foster City, CA 94404 (US)
  • National Research Council of Canada
    Ottawa, Ontario K1A 0R6 (CA)

(72) Inventors:
  • TIKHOMIROV, Ilia Alexandre
    Toronto Ontario M8Z 1P5 (CA)
  • JARAMILLO, Maria L.
    Beaconsfield Québec H9W 2M2 (CA)
  • O'CONNOR-MCCOURT, Maureen D.
    Beaconsfield Québec H9W 1P2 (CA)
  • SULEA, Traian
    Kirkland Québec H9J 3A2 (CA)
  • GILBERT, Renald
    Montreal Québec H4V 2B4 (CA)
  • GAILLET, Bruno
    Sainte Julienne Québec J0K 2T0 (CA)
  • BAARDSNES, Jason
    Montreal Québec H3K 1N8 (CA)
  • BANVILLE, Myriam
    Laval Québec H7X 3K4 (CA)
  • GROTHE, Suzanne
    Montreal Québec H4H 1X8 (CA)

(74) Representative: Greaves Brewster LLP 
Copa House Station Road
Cheddar, Somerset BS27 3AH
Cheddar, Somerset BS27 3AH (GB)


(56) References cited: : 
WO-A1-96/40210
WO-A2-2008/104183
   
  • Ilia A. Tikhomirov ET AL: "Binding Binding Properties of Epidermal Growth Factor Receptor (EGFR) Targeted Monoclonal Antibodies: Factors Contributing to Differences in Observed Clinical Profiles (A36)", AACR Cancer Clinical Trials and Personalized Medicine, 1 August 2008 (2008-08-01), XP055197559, Retrieved from the Internet: URL:http://ymbiosciences.q4web.com/files/d oc_downloads/Nimotuzumab/poster_nimo_AACR_ Translational_Med_2008_v001_q194wg.pdf [retrieved on 2015-06-23]
  • MELARKODE RAMAKRISHNAN ET AL: "Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin", MABS, 1 January 2009 (2009-01-01), pages 41-48, XP055173443,
  • A. TALAVERA ET AL: "Nimotuzumab, an Antitumor Antibody that Targets the Epidermal Growth Factor Receptor, Blocks Ligand Binding while Permitting the Active Receptor Conformation", CANCER RESEARCH, vol. 69, no. 14, 15 July 2009 (2009-07-15) , pages 5851-5859, XP055197598, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-08-4518
  • ARLHEE DIAZ MIQUELI ET AL: "Biological Activity In Vitro of Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies with Different Affinities", HYBRIDOMA, vol. 26, no. 6, 1 December 2007 (2007-12-01), pages 423-432, XP055197602, ISSN: 1554-0014, DOI: 10.1089/hyb.2007.0516
  • CROMBET T ET AL: "Use of the Humanized Anti-Epidermal Growth Factor Receptor Monoclonal Antibody h-R3 in Combination with Advanced Head and Neck Cancer Patients", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, vol. 22, no. 9, 1 May 2004 (2004-05-01), pages 1646-1654, XP008131473, ISSN: 0732-183X, DOI: 10.1200/JCO.2004.03.089
  • STEPHEN I. RUDNICK ET AL: "Affinity and Avidity in Antibody-Based Tumor Targeting", CANCER BIOTHERAPY & RADIOPHARMACEUTICALS, vol. 24, no. 2, 1 April 2009 (2009-04-01), pages 155-161, XP055069540, ISSN: 1084-9785, DOI: 10.1089/cbr.2009.0627
  • MASAYUKI ODA ET AL: "Reevaluation of stoichiometry and affinity/avidity in interactions between anti-hapten antibodies and mono- or multi-valent antigens", MOLECULAR IMMUNOLOGY, vol. 37, no. 18, 1 December 2000 (2000-12-01), pages 1111-1122, XP055197715, ISSN: 0161-5890, DOI: 10.1016/S0161-5890(01)00028-1
  • GRETA GARRIDO ET AL: "Bivalent binding by intermediate affinity of nimotuzumab: A contribution to explain antibody clinical profile", CANCER BIOLOGY & THERAPY, vol. 11, no. 4, 15 February 2011 (2011-02-15), pages 373-382, XP055197571, ISSN: 1538-4047, DOI: 10.4161/cbt.11.4.14097
  • BOLAND, W ET AL.: 'The Emerging Role OfNimotuzumab In The Treatment Of Non-Small Cell Lung Cancer.' BIOLOGICS vol. 4, 09 November 2010, pages 289 - 298, XP055115351
  • DONALDSON, J. M. ET AL.: 'Design And Development Of Masked Therapeutic Antibodies To Limit Off- Target Effects: Application To Anti-EGFR Antibodies.' CANCER BIOL THER vol. 8, November 2009, pages 2147 - 2152, XP009135774
   
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