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<ep-patent-document id="EP12738907B8W1" file="EP12738907W1B8.xml" lang="en" country="EP" doc-number="2668209" kind="B8" correction-code="W1" date-publ="20210811" status="c" dtd-version="ep-patent-document-v1-5-1">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>BDM Ver 1.7.2 (20 November 2019) -  2999001/0</B007EP></eptags></B000><B100><B110>2668209</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20210811</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>12738907.0</B210><B220><date>20120120</date></B220><B240><B241><date>20130813</date></B241><B242><date>20160629</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>201161435510 P</B310><B320><date>20110124</date></B320><B330><ctry>US</ctry></B330></B300><B400><B405><date>20210811</date><bnum>202132</bnum></B405><B430><date>20131204</date><bnum>201349</bnum></B430><B450><date>20201230</date><bnum>202053</bnum></B450><B452EP><date>20200720</date></B452EP><B472><B475><date>20210330</date><ctry>BG</ctry><date>20201230</date><ctry>FI</ctry><date>20201230</date><ctry>HR</ctry><date>20201230</date><ctry>LV</ctry><date>20201230</date><ctry>RS</ctry></B475></B472><B480><date>20210811</date><bnum>202132</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>C07K  16/28        20060101AFI20200108BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61K  39/395       20060101ALI20200108BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61P  35/00        20060101ALI20200108BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>C07K  16/46        20060101ALI20200108BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>FÜR ZELLEN MIT EGFR BEI HOHER DICHTE SELEKTIVE ANTIKÖRPER</B542><B541>en</B541><B542>ANTIBODIES SELECTIVE FOR CELLS PRESENTING EGFR AT HIGH DENSITY</B542><B541>fr</B541><B542>ANTICORPS SÉLECTIFS DES CELLULES PRÉSENTATRICES DES RÉCEPTEURS DE EGF À HAUTE DENSITÉ</B542></B540><B560><B561><text>WO-A1-96/40210</text></B561><B561><text>WO-A2-2008/104183</text></B561><B562><text>Ilia A. Tikhomirov ET AL: "Binding Binding Properties of Epidermal Growth Factor Receptor (EGFR) Targeted Monoclonal Antibodies: Factors Contributing to Differences in Observed Clinical Profiles (A36)", AACR Cancer Clinical Trials and Personalized Medicine, 1 August 2008 (2008-08-01), XP055197559, Retrieved from the Internet: URL:http://ymbiosciences.q4web.com/files/d oc_downloads/Nimotuzumab/poster_nimo_AACR_ Translational_Med_2008_v001_q194wg.pdf [retrieved on 2015-06-23]</text></B562><B562><text>MELARKODE RAMAKRISHNAN ET AL: "Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin", MABS, 1 January 2009 (2009-01-01), pages 41-48, XP055173443,</text></B562><B562><text>A. TALAVERA ET AL: "Nimotuzumab, an Antitumor Antibody that Targets the Epidermal Growth Factor Receptor, Blocks Ligand Binding while Permitting the Active Receptor Conformation", CANCER RESEARCH, vol. 69, no. 14, 15 July 2009 (2009-07-15) , pages 5851-5859, XP055197598, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-08-4518</text></B562><B562><text>ARLHEE DIAZ MIQUELI ET AL: "Biological Activity In Vitro of Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies with Different Affinities", HYBRIDOMA, vol. 26, no. 6, 1 December 2007 (2007-12-01), pages 423-432, XP055197602, ISSN: 1554-0014, DOI: 10.1089/hyb.2007.0516</text></B562><B562><text>CROMBET T ET AL: "Use of the Humanized Anti-Epidermal Growth Factor Receptor Monoclonal Antibody h-R3 in Combination with Advanced Head and Neck Cancer Patients", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, vol. 22, no. 9, 1 May 2004 (2004-05-01), pages 1646-1654, XP008131473, ISSN: 0732-183X, DOI: 10.1200/JCO.2004.03.089</text></B562><B562><text>STEPHEN I. RUDNICK ET AL: "Affinity and Avidity in Antibody-Based Tumor Targeting", CANCER BIOTHERAPY &amp; RADIOPHARMACEUTICALS, vol. 24, no. 2, 1 April 2009 (2009-04-01), pages 155-161, XP055069540, ISSN: 1084-9785, DOI: 10.1089/cbr.2009.0627</text></B562><B562><text>MASAYUKI ODA ET AL: "Reevaluation of stoichiometry and affinity/avidity in interactions between anti-hapten antibodies and mono- or multi-valent antigens", MOLECULAR IMMUNOLOGY, vol. 37, no. 18, 1 December 2000 (2000-12-01), pages 1111-1122, XP055197715, ISSN: 0161-5890, DOI: 10.1016/S0161-5890(01)00028-1</text></B562><B562><text>GRETA GARRIDO ET AL: "Bivalent binding by intermediate affinity of nimotuzumab: A contribution to explain antibody clinical profile", CANCER BIOLOGY &amp; THERAPY, vol. 11, no. 4, 15 February 2011 (2011-02-15), pages 373-382, XP055197571, ISSN: 1538-4047, DOI: 10.4161/cbt.11.4.14097</text></B562><B562><text>BOLAND, W ET AL.: 'The Emerging Role OfNimotuzumab In The Treatment Of Non-Small Cell Lung Cancer.' BIOLOGICS vol. 4, 09 November 2010, pages 289 - 298, XP055115351</text></B562><B562><text>DONALDSON, J. M. ET AL.: 'Design And Development Of Masked Therapeutic Antibodies To Limit Off- Target Effects: Application To Anti-EGFR Antibodies.' CANCER BIOL THER vol. 8, November 2009, pages 2147 - 2152, XP009135774</text></B562><B565EP><date>20150703</date></B565EP></B560></B500><B700><B720><B721><snm>TIKHOMIROV, Ilia Alexandre</snm><adr><str>954 The Queensway</str><city>Toronto
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