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(11)

EP 2 675 446 A1

(12)

(43) Date of publication: 25.12.2013 Bulletin 2013/52 (21) Application number: 12707420.1 (22) Date of filing: 14.02.2012

(51) International Patent Classification (IPC):  A61K 31/202(2006.01) A61P 9/00(2006.01) A61K 45/06(2006.01) (86) International application number: PCT/US2012/025021 (87) International publication number: WO 2012/112527 (23.08.2012 Gazette 2012/34)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 16.02.2011 US 201161457271 P (71) Applicant: Pivotal Therapeutics, Inc. Woodbridge, Ontario L4H 0S5 (CA)	(72) Inventors: JACKOWSKI, George Kettleby, Ontario LOG 1J0 (CA) MACSWEENEY, Rachelle Kettleby, Ontario L0G 1J0 (CA) SHAIKH, Nisar Mississauga, Ontario L5V 1B5 (CA) YANTHA, Jason Brampton, Ontario L6Y 1T2 (CA) SCHINI-KERTH, Valerie F-67117 Fessenheim-le-Bas (FR) (74) Representative: Kremer, Simon Mark et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)