(19)
(11) EP 2 683 711 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
23.08.2017 Bulletin 2017/34

(45) Mention of the grant of the patent:
01.02.2017 Bulletin 2017/05

(21) Application number: 12754287.6

(22) Date of filing: 06.03.2012
(51) International Patent Classification (IPC): 
C07D 237/16(2006.01)
C07D 401/04(2006.01)
C07D 403/04(2006.01)
C07D 405/14(2006.01)
C07D 413/04(2006.01)
A61P 29/00(2006.01)
C07D 237/24(2006.01)
C07D 401/14(2006.01)
C07D 405/04(2006.01)
C07D 409/04(2006.01)
A61K 31/50(2006.01)
(86) International application number:
PCT/FI2012/050220
(87) International publication number:
WO 2012/120195 (13.09.2012 Gazette 2012/37)

(54)

NEW PYRIDAZINONE AND PYRIDONE COMPOUNDS

NEUE PYRIDAZINON- UND PYRIDONVERBINDUNGEN

NOUVEAUX COMPOSÉS DE PYRIDAZINONE ET PYRIDONE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 08.03.2011 FI 20115234
08.03.2011 US 201161450352 P

(43) Date of publication of application:
15.01.2014 Bulletin 2014/03

(73) Proprietor: Biotie Therapies Corp.
20520 Turku (FI)

(72) Inventors:
  • PIHLAVISTO, Marjo
    FI-20520 Turku (FI)
  • SMITH, David
    FI-20520 Turku (FI)
  • JUHAKOSKI, Auni
    FI-20520 Turku (FI)
  • FULOP, Ferenc
    FI-20520 Turku (FI)
  • LAZAR, Laszlo
    FI-20520 Turku (FI)
  • SZATMARI, Istvan
    FI-20520 Turku (FI)
  • MIKLOS, Ferenc
    FI-20520 Turku (FI)
  • SZAKONYI, Zsolt
    FI-20520 Turku (FI)
  • KISS, Lorand
    FI-20520 Turku (FI)
  • PALKO, Marta
    FI-20520 Turku (FI)

(74) Representative: Kolster Oy Ab 
Salmisaarenaukio 1
00180 Helsinki
00180 Helsinki (FI)


(56) References cited: : 
EP-A1- 1 847 535
WO-A1-2010/029379
JP-A- 2003 040 872
WO-A1-2008/115381
WO-A2-2004/072029
   
  • JOHN HOWARD BIRKINSHAW ET AL: "LXIV. Studies in the biochemistry of micro-organisms. XLVIII. Penicillic acid, a metabolic product of Penicillium puberulum Bainier and P. cyclopium Westling", BIOCHEMICAL JOURNAL, vol. 30, no. 3, 1936, pages 394-411, XP055123476,
  • HANS JÜRGEN BESTMANN ET AL: "Kumulierte Ylide, XIV. Phosphacumulen-Ylide als Cyclisierungsbausteine in der Heterocyclensynthese", CHEMISCHE BERICHTE, vol. 118, no. 4, 1985, pages 1709-1719, XP055123470, ISSN: 0009-2940, DOI: 10.1002/cber.19851180436
  • BERNT D. SCHOBER ET AL: "Pyridazines with heteroatom substituents in position 3 and 5. 3. 2-Aryl-5-hydroxypyridazin-3(2H)-ones as potential herbicides: synthesis and some reactions", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 26, no. 1, 1989, pages 169-176, XP002051833, ISSN: 0022-152X, DOI: 10.1002/JHET.5570260130
  • RAFAT MILAD MOHAREB ET AL: "Novel synthesis of 4-bromo-3-oxo-2-phenylhydrazono-butyronitr ile and 4-cyano-3-oxo-2-phenylhydrazono-butyronitr ile: synthesis of pyridazine, thiazole, 1,2,4-triazine and pyrido[2,3-e]-1,2,4-triazine derivatives", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 57, no. 8, 1992, pages 1758-1769, XP009178541, DOI: 10.1135/cccc19921758
  • SCHOBER, B.D. ET AL.: 'Pyridazines with hetero-atom substituents in position 3 and 5, part VII [1]. Halogenation of 2-aryl-5-hydroxy-pyridazin-3(2H)-ones in position 4.' MONATSHEFTE FUR CHEMIE vol. 121, 1990, pages 565 - 569, XP002475412
  • ZUPANCIC S. ET AL.: 'Transformations of dialkyl acetone-1,3-dicarboxylates 1. via their dimethylaminomethylidene derivatives into 1-substituted 4-ethoxycarbonyl-5-(ethoxycarbonylmethyl)py razoles, 7-amino-2-ethoxycarbonyl-1 H,2H-pyrazolo[2,3-c]pyrimidin-5-one, 4-hydroxypyridin-2(1H)-ones and 6-substituted 3-benzoylamino-' ACTA CHIM. SLOV. vol. 55, no. 4, 2008, pages 1009 - 1018, XP055127949
  • FAHMY, S.M. ET AL.: 'Activated nitriles in heterocyclic synthesis: a novel synthesis of pyridine and pyridazine derivatives.' SYNTHESIS 1985, pages 1135 - 1137, XP008170455
   
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