(19)
(11) EP 2 698 365 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
14.02.2018 Bulletin 2018/07

(45) Mention of the grant of the patent:
13.12.2017 Bulletin 2017/50

(21) Application number: 12771389.9

(22) Date of filing: 02.04.2012
(51) International Patent Classification (IPC): 
C07D 487/04(2006.01)
C07C 251/86(2006.01)
A61L 27/00(2006.01)
 C07D 307/52(2006.01)
C07C 43/225(2006.01)
C12N 5/071(2010.01)
(86) International application number:
PCT/JP2012/059021
(87) International publication number:
WO 2012/141038 (18.10.2012 Gazette 2012/42)

(54)

SYNTHESIS AND ANALYSIS OF NOVEL COMPOUND CAPABLE OF INDUCING DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELL INTO HEPATOCYTE

SYNTHESE UND ANALYSE EINER NEUEN VERBINDUNG ZUR INDUZIERUNG DER DIFFERENZIERUNG MENSCHLICHER MESENCHYMALER STAMMZELLEN IN HEPATOZYTEN

SYNTHÈSE ET ANALYSE DE NOUVEAU COMPOSÉ APTE À INDUIRE LA DIFFÉRENCIATION DE CELLULE SOUCHE MÉSENCHYMATEUSE HUMAINE EN HÉPATOCYTE

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 15.04.2011 JP 2011091599

(43) Date of publication of application:
19.02.2014 Bulletin 2014/08

(73) Proprietors:
  • National University Corporation Tottori University
    Tottori-shi Tottori 680-8550 (JP)
  • Tokyo Women's Medical University
    Tokyo 162-8666 (JP)
  • KanonCure, Inc.
    Tottori 6838504 (JP)
    Designated Contracting States:
    ES IT 

(72) Inventors:
  • SHIOTA, Goshi
    Yonago-shi Tottori 683-8503 (JP)
  • HOSHIKAWA, Yoshiko
    Yonago-shi Tottori 683-8503 (JP)
  • MATSUMOTO, Noriko
    Yonago-shi Tottori 683-8503 (JP)
  • MATSUMI, Yoshiaki
    Yonago-shi Tottori 683-8503 (JP)
  • MORIMOTO, Minoru
    Tottori-shi Tottori 680-8550 (JP)
  • TONOI, Takayuki
    Tottori-shi Tottori 680-8550 (JP)
  • SAIMOTO, Hiroyuki
    Tottori-shi Tottori 680-8550 (JP)
  • OHASHI, Kazuo
    Tokyo 162-8666 (JP)
  • OKANO, Teruo
    Tokyo 162-8666 (JP)

(74) Representative: Gulde & Partner 
Patent- und Rechtsanwaltskanzlei mbB Wallstraße 58/59
10179 Berlin
10179 Berlin (DE)


(56) References cited: : 
WO-A1-2007/139346
JP-A- 2010 523 579
 JP-A- 2007 503 816
JP-A- 2011 219 435
   
  • Y. YOSHIDA ET AL: "A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells", AMERICAN JOURNAL OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 293, no. 5, 27 September 2007 (2007-09-27), pages G1089-G1098, XP055156094, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00187.2007
  • ISHII KYOKO ET AL: "Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3 beta", HEPATOLOGY, JOHN WILEY & SONS, INC, USA, vol. 48, no. 2, 1 August 2008 (2008-08-01) , pages 597-606, XP009136907, ISSN: 0270-9139
  • MCMILLAN ET AL: "Investigating Wnt signaling: a chemogenomic safari", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 10, no. 21, 1 November 2005 (2005-11-01), pages 1467-1474, XP005124585, ISSN: 1359-6446, DOI: 10.1016/S1359-6446(05)03613-5
  • PIERGENTILI ET AL: "Solution-phase synthesis of ICG-001, a beta-turn peptidomimetic molecule inhibitor of beta-catenin-Tcf-mediated transcription", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 63, no. 52, 13 October 2007 (2007-10-13), pages 12912-12916, XP022350754, ISSN: 0040-4020, DOI: 10.1016/J.TET.2007.10.048
  • YOSHIAKI MATSUMI ET AL.: 'Hito Kotsuzui Yurai Kan'yo-kei Kansaibo o Kinosei Kansaibo e Bunka Yudo Sayo o Motsu Wnt/p-catenin Signal Yokuseisei Teibunshi Kagobutsu no Dotei ni yoru Kan Saisei Iryo Kaihatsu' ACTA HEPATOLOGICA JAPONICA vol. 51, no. 1, 30 April 2010, page A259, XP008171762
   
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