| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
13.04.2011 JP 2011088762
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| (43) |
Date of publication of application: |
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19.02.2014 Bulletin 2014/08 |
| (73) |
Proprietor: Nihon Pharmaceutical Co., Ltd. |
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Chuo-ku,
Tokyo 104-0044 (JP) |
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| (72) |
Inventors: |
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- KOGURE, Takahisa
Chiba 286-0825 (JP)
- NAKAJIMA, Kenji
Osaka 598-0061 (JP)
- HOMMA, Masayuki
Narita-shi
Chiba 286-0825 (JP)
|
| (74) |
Representative: Patentanwälte
Ruff, Wilhelm, Beier, Dauster & Partner mbB |
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Kronenstraße 30 70174 Stuttgart 70174 Stuttgart (DE) |
| (56) |
References cited: :
WO-A1-2011/013470 WO-A2-2004/110472 JP-A- 9 077 800 JP-A- 2011 032 188
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WO-A2-03/068822 DE-A1- 10 160 248 JP-A- 2007 505 643
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- CHANG T ET AL: "Selective recognition and elimination of nicotinic acetylcholine receptor-reactive
B cells by a recombinant fusion protein AChR-Fc in myasthenia gravis in vitro", JOURNAL
OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 227, no. 1-2, 8 October
2010 (2010-10-08), pages 35-43, XP027288214, ISSN: 0165-5728 [retrieved on 2010-08-19]
- ZOCHER M ET AL: "SPECIFIC DEPLETION OF AUTOREACTIVE B LYMPHOCYTES BY A RECOMBINANT
FUSION PROTEIN IN VITRO AND IN VIVO", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY
PRESS, GB, vol. 15, no. 7, 1 July 2003 (2003-07-01), pages 789-796, XP001155918, ISSN:
0953-8178, DOI: 10.1093/INTIMM/DXG076
- ZOCHER M. ET AL.: 'Specific depletion of autoreactive B lymphocytes by a recombinant
fusion protein in vitro and in vivo' INT. IMMUNOL. vol. 15, no. 7, 2003, pages 789
- 796, XP001155918
- TSOULOUFIS T. ET AL.: 'Reconstitution of conformationally dependent epitopes on the
N-terminal extracellular domain of the human muscle acetylcholine receptor alpha subunit
expressed in Escherichia coli: implications for myasthenia gravis therapeutic approaches'
INT. IMMUNOL. vol. 12, no. 9, 2000, pages 1255 - 1265, XP008148987
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