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EP 2 699 262 A2

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(88) Date of publication A3: 03.01.2013 (43) Date of publication: 26.02.2014 Bulletin 2014/09 (21) Application number: 12718626.0 (22) Date of filing: 20.04.2012

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) C07K 16/32(2006.01) C07K 16/28(2006.01) A61K 47/48(2006.01) A61P 35/00(2006.01) C07K 16/10(2006.01) C07K 16/46(2006.01) (86) International application number: PCT/EP2012/057307 (87) International publication number: WO 2012/143524 (26.10.2012 Gazette 2012/43)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 20.04.2011 WO PCT/EP2011/056388 20.04.2011 DK 201100312 27.05.2011 WO PCT/EP2011/058772 27.05.2011 WO PCT/EP2011/058779 27.10.2011 DK 201100824 27.10.2011 US 201161552286 P (71) Applicant: Genmab A/S 1260 Copenhagen K (DK)

(72) Inventors: NEIJSEEN, Joost, J. NL-3584 CM Utrecht (NL) MEESTERS, Joyce, I. NL-3584 Utrecht (NL) DE GOEIJ, Bart NL-3584 CM Utrecht (NL) LABRIJN, Aran, Frank NL-3584 CM Utrecht (NL) PARREN, Paul NL-3584 CM Utrecht (NL) SCHUURMAN, Janine NL-3584 CM Utrecht (NL) (74) Representative: Genmab A/S  Bredgade 34 E 1260 Copenhagen K 1260 Copenhagen K (DK)