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EP 2 702 043 A1

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(43) Date of publication: 05.03.2014 Bulletin 2014/10 (21) Application number: 12725560.2 (22) Date of filing: 30.04.2012

(51) International Patent Classification (IPC):  C07D 239/42(2006.01) C07D 403/04(2006.01) C07D 405/04(2006.01) C07D 405/14(2006.01) C07D 413/04(2006.01) C07D 417/14(2006.01) A61P 35/00(2006.01) C07D 401/04(2006.01) C07D 403/12(2006.01) C07D 405/12(2006.01) C07D 409/04(2006.01) C07D 417/04(2006.01) A61K 31/506(2006.01) (86) International application number: PCT/US2012/035794 (87) International publication number: WO 2012/149528 (01.11.2012 Gazette 2012/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 29.04.2011 US 201161481035 P (71) Applicant: Exelixis, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: TSUHAKO, Amy, Lew Milpitas, CA 95035 (US) MARLOWE, Charles, K. Emerald Hills, CA 94062 (US) ZAHARIA, Christiana, A. Redwood City, CA 94061 (US) KABIGTING, Lori South San Francisco, CA 94116 (US) BAJJALIEH, William San Francisco, CA 94116 (US) TESFAI, Zerom Castro Valley, CA 94522 (US) HUANG, Ping Mountain View, CA 94040 (US) MOON, Kim Palo Alto, CA 94303 (US) AAY, Naing San Mateo, CA 94401 (US) TAMBO-ONG, Arlyn South San Francisco, CA 94080 (US) NUSS, John, M. Danville, CA 94506 (US) XU, Wei Danville, CA 94526 (US) KEARNEY, Patrick San Francisco, CA 94110 (US) (74) Representative: Main, Malcolm Charles  Murgitroyd & Company Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)